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    csl4 putative exosome subunit Csl4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539351, updated on 11-Apr-2024

    Summary

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    Gene symbol
    csl4
    Gene description
    putative exosome subunit Csl4
    Primary source
    PomBase:SPCC1840.11
    Locus tag
    SPCC1840.11
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCC965.01
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (2279333..2280286)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene putative U6 snRNP-associated protein Lsm8 Neighboring gene miscRNA Neighboring gene putative OPT oligopeptide transporter family protein Neighboring gene putative V-type ATPase V1 subunit D Neighboring gene miscRNA Neighboring gene putative i-AAA protease Yme1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA exosome promotes transcription termination of backtracked RNA polymerase II. Lemay JF, et al. Nat Struct Mol Biol, 2014 Oct. PMID 25240800
    2. Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex. Weick EM, et al. Cell, 2018 Jun 14. PMID 29906447, Free PMC Article
    3. The Sm complex is required for the processing of non-coding RNAs by the exosome. Coy S, et al. PLoS One, 2013. PMID 23755256, Free PMC Article
    4. The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway. Malecki M, et al. EMBO J, 2013 Jul 3. PMID 23503588, Free PMC Article
    5. Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome. Telekawa C, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30321377, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables RNA binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in TRAMP-dependent tRNA surveillance pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nonfunctional rRNA decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear mRNA surveillance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear polyadenylation-dependent mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear polyadenylation-dependent rRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, non-stop decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol HDA PubMed 
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    putative exosome subunit Csl4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2279333..2280286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023500.2 → NP_588510.1  putative exosome subunit Csl4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588510.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O59821
      Conserved Domains (2) summary
      COG1096
      Location:1 → 181
      Csl4; Exosome complex RNA-binding protein Csl4, contains S1 and Zn-ribbon domains [Translation, ribosomal structure and biogenesis]
      cd05791
      Location:53 → 143
      S1_CSL4; S1_CSL4: CSL4, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. ScCSL4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation ...
    Nucleotide Protein
    Heading Accession and Version

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