1: Mapk10 mitogen activated protein kinase 10 [ Rattus norvegicus ]

GeneID: 25272 updated 22-Oct-2009

[Top][Help]Summary

Official Symbol
Mapk10provided by RGD
Official Full Name
mitogen activated protein kinase 10provided by RGD
Primary Source
RGD:3663
See related
Ensembl:ENSRNOG00000002079; RATMAP:41156
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Jnk3; SAPb; SAPKC; Serk2; Mapk10
Summary
a stress-activated protein kinase [RGD]

[Top][Help]Genomic regions, transcripts, and products

(plus) Go to reference sequence detailsTry our new Sequence Viewer


[Top][Help]Bibliography

Related Articles in PubMed

GeneRIFs: Gene References Into Function What's a GeneRIF?

PubMed 1. In a neonatal rat model of pneumococcal meningitis, JNK3 (but not JNK1 or JNK2) is activated in the hippocampus during the acute phase of infection and may be involved in processes unrelated to apoptosis in this disease.
PubMed 2. A prominent role for JNK3 is the maintenance of cellular differentiation in glia cells; expression of JNK3 protein and mRNA are increased in growth arrested C6 glioma cells.
PubMed 3. JNK3 apoptotic signaling pathway is attentuated by stimulating GABA receptors via inhibiting the increased assembly of the GluR6-PSD-95-MLK3 signaling module in cerebral ischemia
PubMed 4. interaction of free arrestins with JNK3 and Mdm2 and their ability to regulate subcellular localization of these proteins may play an important role in the survival of photoreceptors and other neurons
PubMed 5. These findings strongly suggest that Cdc42 serves as an upstream activator and modulates JNK-mediated apoptosis machinery in vivo, which ultimately results in neuronal apoptosis via nuclear and non-nuclear pathways.
PubMed 6. K252a plays a neuroprotective role in ischemic injury via inhibition of the JNK pathway (MKK7 AND JNK3)
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[Top][Help]General gene information

Markers

RH131900(e-PCR)
Links: UniSTS:215183
RH139507(e-PCR)
Links: UniSTS:221593
RH137759(e-PCR)
Links: UniSTS:219846
BE120200(e-PCR)
Links: UniSTS:247266
BF393702(e-PCR)
Links: UniSTS:244217

Homology

Homologs of the Mapk10 gene The Mapk10 gene is conserved in human, chimpanzee, dog, cow, mouse, chicken, zebrafish, fruit fly, mosquito, and C.elegans.


Map Viewer (Human, Mouse)

Pathways

KEGG pathway: Adipocytokine signaling pathway
04920
KEGG pathway: Colorectal cancer
05210
KEGG pathway: ErbB signaling pathway
04012
KEGG pathway: Fc epsilon RI signaling pathway
04664
KEGG pathway: Focal adhesion
04510
KEGG pathway: GnRH signaling pathway
04912
KEGG pathway: Insulin signaling pathway
04910
KEGG pathway: MAPK signaling pathway
04010
KEGG pathway: Neurotrophin signaling pathway
04722
KEGG pathway: Pancreatic cancer
05212
KEGG pathway: Pathways in cancer
05200
KEGG pathway: RIG-I-like receptor signaling pathway
04622
KEGG pathway: Toll-like receptor signaling pathway
04620
KEGG pathway: Type II diabetes mellitus
04930
KEGG pathway: Wnt signaling pathway
04310

[Top][Help]General protein information

Preferred Names
mitogen activated protein kinase 10
Names
mitogen activated protein kinase 10
Stress activated protein kinase beta
NP_036938.1
EC 2.7.11.24

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

mRNA and Protein(s)

  1. NM_012806.1 → NP_036938.1  mitogen activated protein kinase 10

    Source sequence(s)
    L27128
    UniProtKB/Swiss-Prot
    P49187
    Conserved Domains (2) summary
    cd00180
    Location:25 – 321
    Blast Score: 642
    S_TKc; Serine/Threonine protein kinases, catalytic domain. Phosphotransferases of the serine or threonine-specific kinase subfamily. The enzymatic activity of these protein kinases is controlled by phosphorylation of specific residues in the activation...
    smart00220
    Location:38 – 321
    Blast Score: 651
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 4.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC v3.4)

Genomic

  1. NC_005113.2

    Range
    7719594..8010693
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_047421.1 

    Range
    2662221..2953320
    Download
    GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (based on Celera assembly)

Genomic

  1. AC_000082.1

    Range
    6636701..6918634
    Download
    GenBank FASTA Sequence Viewer (Graphics)

  2. NW_001084689.1 

    Range
    2562119..2844052
    Download
    GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

  Nucleotide   Protein Strain
  genomic   CH474022.1   EDL99526.1
       EDL99527.1
  mRNA   DQ377224.1   ABD24063.1   Sprague-Dawley
  mRNA   L27128.1   AAA42110.1
Protein Accession   Links
P49187.2   GenPept   UniProtKB/Swiss-Prot:P49187

[Top][Help]Additional Links