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    Rpp38 ribonuclease P/MRP 38 subunit [ Mus musculus (house mouse) ]

    Gene ID: 227522, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rpp38provided by MGI
    Official Full Name
    ribonuclease P/MRP 38 subunitprovided by MGI
    Primary source
    MGI:MGI:2443607
    See related
    Ensembl:ENSMUSG00000049950 AllianceGenome:MGI:2443607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C330006A15Rik
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to act upstream of or within rRNA processing and tRNA processing. Predicted to be located in nucleolus. Predicted to be part of multimeric ribonuclease P complex. Predicted to be active in fibrillar center. Orthologous to human RPP38 (ribonuclease P/MRP subunit p38). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 12.8), CNS E18 (RPKM 9.7) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 A1; 2 1.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3328305..3334023, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3326548..3332986, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member A1 Neighboring gene predicted gene, 54098 Neighboring gene STARR-seq mESC enhancer starr_03511 Neighboring gene predicted gene, 22005 Neighboring gene N-myristoyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene oleoyl-ACP hydrolase Neighboring gene STARR-seq mESC enhancer starr_03512 Neighboring gene predicted gene, 39750

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao S, et al. Annu Rev Biochem, 2002. PMID 12045094, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ribonuclease P RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribonuclease P activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in fibrillar center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of multimeric ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleolar ribonuclease P complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P protein subunit p38
    Names
    RNaseP protein p38
    ribonuclease P/MRP 38kDa subunit
    NP_001013394.2
    XP_006497513.1
    XP_006497514.1
    XP_030105367.1
    XP_030105369.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013376.2 → NP_001013394.2  ribonuclease P protein subunit p38

      See identical proteins and their annotated locations for NP_001013394.2

      Status: VALIDATED

      Source sequence(s)
      AL732620
      Consensus CDS
      CCDS15645.1
      UniProtKB/Swiss-Prot
      Q3UTW5, Q80UU2, Q8BU46
      UniProtKB/TrEMBL
      A2AJG0
      Related
      ENSMUSP00000050992.7, ENSMUST00000062672.7
      Conserved Domains (1) summary
      pfam01248
      Location:102 → 180
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3328305..3334023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497450.5 → XP_006497513.1  ribonuclease P protein subunit p38 isoform X2

      See identical proteins and their annotated locations for XP_006497513.1

      UniProtKB/Swiss-Prot
      Q3UTW5, Q80UU2, Q8BU46
      UniProtKB/TrEMBL
      A2AJG0
      Conserved Domains (1) summary
      pfam01248
      Location:102 → 180
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    2. XM_030249509.2 → XP_030105369.1  ribonuclease P protein subunit p38 isoform X2

      UniProtKB/Swiss-Prot
      Q3UTW5, Q80UU2, Q8BU46
      UniProtKB/TrEMBL
      A2AJG0
      Conserved Domains (1) summary
      pfam01248
      Location:102 → 180
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    3. XM_030249507.2 → XP_030105367.1  ribonuclease P protein subunit p38 isoform X1

      UniProtKB/Swiss-Prot
      Q3UTW5, Q80UU2, Q8BU46
      Conserved Domains (1) summary
      pfam01248
      Location:172 → 250
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    4. XM_006497451.5 → XP_006497514.1  ribonuclease P protein subunit p38 isoform X2

      See identical proteins and their annotated locations for XP_006497514.1

      UniProtKB/Swiss-Prot
      Q3UTW5, Q80UU2, Q8BU46
      UniProtKB/TrEMBL
      A2AJG0
      Conserved Domains (1) summary
      pfam01248
      Location:102 → 180
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UU2.1 GenPept UniProtKB/Swiss-Prot:Q80UU2

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