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    Zfp180 zinc finger protein 180 [ Mus musculus (house mouse) ]

    Gene ID: 210135, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Zfp180provided by MGI
    Official Full Name
    zinc finger protein 180provided by MGI
    Primary source
    MGI:MGI:1923701
    See related
    Ensembl:ENSMUSG00000057101 AllianceGenome:MGI:1923701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HHZ168; D130011P11; 2310040I01Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Is expressed in several structures, including central nervous system; eye; genitourinary system; limb; and liver. Orthologous to human ZNF180 (zinc finger protein 180). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 11.9), whole brain E14.5 (RPKM 10.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 A3; 7 10.27 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (23781303..23807134)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24081877..24107709)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene prothymosin alpha, pseudogene 1 Neighboring gene predicted gene, 36694 Neighboring gene STARR-seq mESC enhancer starr_18250 Neighboring gene zinc finger protein 112 Neighboring gene STARR-positive B cell enhancer ABC_E2817 Neighboring gene zinc finger protein 235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 180

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045486.2 → NP_001038951.1  zinc finger protein 180 isoform a

      See identical proteins and their annotated locations for NP_001038951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC121271, AK141922, BC066115
      Consensus CDS
      CCDS39823.1
      UniProtKB/TrEMBL
      Q6NZI9
      Related
      ENSMUSP00000064611.4, ENSMUST00000068975.6
      Conserved Domains (4) summary
      COG5048
      Location:297 → 650
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:488 → 508
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:318 → 340
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:528 → 553
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001289634.1 → NP_001276563.1  zinc finger protein 180 isoform b

      See identical proteins and their annotated locations for NP_001276563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an additional internal exon, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AC121271, AK141922, BC066115, BQ771416
      UniProtKB/TrEMBL
      Q6NZI9
      Conserved Domains (4) summary
      COG5048
      Location:273 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:464 → 484
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294 → 316
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:504 → 529
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001289637.1 → NP_001276566.1  zinc finger protein 180 isoform b

      See identical proteins and their annotated locations for NP_001276566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AC121271, AK141922, BC066115, CF736119
      UniProtKB/TrEMBL
      Q6NZI9
      Conserved Domains (4) summary
      COG5048
      Location:273 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:464 → 484
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:294 → 316
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:504 → 529
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001289640.1 → NP_001276569.1  zinc finger protein 180 isoform c

      See identical proteins and their annotated locations for NP_001276569.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, and it thus differs in its 5' UTR and initiates translation from an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct and shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC121271, AK141922, BC066115
      UniProtKB/TrEMBL
      Q6P407
      Conserved Domains (3) summary
      COG5048
      Location:263 → 616
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:454 → 474
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:494 → 519
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001289641.1 → NP_001276570.1  zinc finger protein 180 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, and it thus differs in its 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC121271, AK141922, BC066115
      UniProtKB/TrEMBL
      Q6NZI9
      Conserved Domains (3) summary
      COG5048
      Location:237 → 590
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:428 → 448
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:468 → 493
      zf-H2C2_2; Zinc-finger double domain

    6. NM_172483.2 → NP_766071.1  zinc finger protein 180 isoform e

      See identical proteins and their annotated locations for NP_766071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two internal exons, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC121271, AK083802
      UniProtKB/TrEMBL
      Q8BJI2
      Conserved Domains (3) summary
      COG5048
      Location:148 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313 → 333
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:437 → 462
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      23781303..23807134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242320.2 → XP_030098180.1  zinc finger protein 180 isoform X1

      UniProtKB/TrEMBL
      Q8BJI2
      Conserved Domains (3) summary
      COG5048
      Location:148 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313 → 333
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:437 → 462
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036152867.1 → XP_036008760.1  zinc finger protein 180 isoform X1

      UniProtKB/TrEMBL
      Q8BJI2
      Conserved Domains (3) summary
      COG5048
      Location:148 → 410
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:313 → 333
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:437 → 462
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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