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    Gps1 G protein pathway suppressor 1 [ Mus musculus (house mouse) ]

    Gene ID: 209318, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gps1provided by MGI
    Official Full Name
    G protein pathway suppressor 1provided by MGI
    Primary source
    MGI:MGI:2384801
    See related
    Ensembl:ENSMUSG00000025156 AllianceGenome:MGI:2384801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csn1; Sgn1; Cops1
    Summary
    Predicted to be involved in protein deneddylation. Part of COP9 signalosome. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human GPS1 (G protein pathway suppressor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 101.5), testis adult (RPKM 81.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 E2; 11 84.54 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120675086..120679928)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120784260..120789102)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31367 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120637476-120637735 Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene dihydrouridine synthase 1 like Neighboring gene fatty acid synthase Neighboring gene STARR-positive B cell enhancer ABC_E9039 Neighboring gene coiled-coil domain containing 57 Neighboring gene STARR-seq mESC enhancer starr_31373 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120794121-120794304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome. Horváth A, et al. BMC Mol Cell Biol, 2020 May 8. PMID 32384871, Free PMC Article
    2. Expression pattern of the JAB1/CSN5 gene during murine embryogenesis: colocalization with NEDD8. Carrabino S, et al. Gene Expr Patterns, 2004 Jul. PMID 15183309
    3. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. Tomoda K, et al. J Biol Chem, 2004 Oct 8. PMID 15299027
    4. Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity. Li JY, et al. Cell Signal, 2007 Jun. PMID 17276034, Free PMC Article
    5. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Lykke-Andersen K, et al. Mol Cell Biol, 2003 Oct. PMID 12972599, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome.
      Title: Interaction between NSMCE4A and GPS1 links the SMC5/6 complex to the COP9 signalosome.
    2. The present study demonstrates that Asb-4 interacts with GPS1 and inhibits JNK activity.
      Title: Ankyrin repeat and SOCS box containing protein 4 (Asb-4) interacts with GPS1 (CSN1) and inhibits c-Jun NH2-terminal kinase activity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7191, MGC118012

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 1
    Names
    JAB1-containing signalosome subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177874.2 → NP_001171345.1  COP9 signalosome complex subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_001171345.1

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS49011.1
      UniProtKB/TrEMBL
      Q3MIA8
      Related
      ENSMUSP00000112007.2, ENSMUST00000116305.8
      Conserved Domains (2) summary
      pfam01399
      Location:320 → 424
      PCI; PCI domain
      pfam10602
      Location:123 → 305
      RPN7; 26S proteasome subunit RPN7

    2. NM_001346709.2 → NP_001333638.1  COP9 signalosome complex subunit 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS83950.1
      UniProtKB/TrEMBL
      B1ATU4
      Related
      ENSMUSP00000097711.4, ENSMUST00000100134.10
      Conserved Domains (2) summary
      pfam01399
      Location:320 → 424
      PCI; PCI domain
      pfam10602
      Location:123 → 305
      RPN7; 26S proteasome subunit RPN7

    3. NM_001363440.1 → NP_001350369.1  COP9 signalosome complex subunit 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS88299.1
      UniProtKB/TrEMBL
      A0A140LJB7
      Related
      ENSMUSP00000147152.2, ENSMUST00000208737.2
      Conserved Domains (2) summary
      pfam01399
      Location:319 → 423
      PCI; PCI domain
      pfam10602
      Location:123 → 304
      RPN7; 26S proteasome subunit RPN7

    4. NM_001405272.1 → NP_001392201.1  COP9 signalosome complex subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL663090

    5. NM_001405273.1 → NP_001392202.1  COP9 signalosome complex subunit 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL663090

    6. NM_001405274.1 → NP_001392203.1  COP9 signalosome complex subunit 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL663090

    7. NM_001405275.1 → NP_001392204.1  COP9 signalosome complex subunit 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL663090

    8. NM_145370.4 → NP_663345.2  COP9 signalosome complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_663345.2

      Status: VALIDATED

      Source sequence(s)
      AL663090
      Consensus CDS
      CCDS25758.2
      UniProtKB/TrEMBL
      G3UXW9
      Related
      ENSMUSP00000133855.2, ENSMUST00000172809.2
      Conserved Domains (2) summary
      pfam01399
      Location:359 → 463
      PCI; PCI domain
      pfam10602
      Location:162 → 344
      RPN7; 26S proteasome subunit RPN7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120675086..120679928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314411.1 → XP_017169900.1  COP9 signalosome complex subunit 1 isoform X4

      Conserved Domains (2) summary
      pfam01399
      Location:319 → 423
      PCI; PCI domain
      pfam10602
      Location:123 → 304
      RPN7; 26S proteasome subunit RPN7

    2. XM_006532744.3 → XP_006532807.1  COP9 signalosome complex subunit 1 isoform X1

      Conserved Domains (2) summary
      pfam01399
      Location:359 → 463
      PCI; PCI domain
      pfam10602
      Location:162 → 344
      RPN7; 26S proteasome subunit RPN7

    3. XM_017314409.2 → XP_017169898.1  COP9 signalosome complex subunit 1 isoform X2

      Conserved Domains (2) summary
      pfam01399
      Location:358 → 462
      PCI; PCI domain
      pfam10602
      Location:162 → 343
      RPN7; 26S proteasome subunit RPN7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99LD4.1 GenPept UniProtKB/Swiss-Prot:Q99LD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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