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    Zc3h14 zinc finger CCCH type containing 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192359, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Zc3h14provided by RGD
    Official Full Name
    zinc finger CCCH type containing 14provided by RGD
    Primary source
    RGD:621850
    See related
    Ensembl:ENSRNOG00000004083 AllianceGenome:RGD:621850
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Npuk68
    Summary
    Predicted to enable poly(A) binding activity. Predicted to be involved in negative regulation of mRNA polyadenylation and regulation of mRNA stability. Located in nuclear speck. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 269.9), Adrenal (RPKM 170.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123736120..123773775)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (118006420..118044480)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122729834..122767462)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 7 Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene uncharacterized LOC134479245 Neighboring gene EMAP like 5 Neighboring gene tetratricopeptide repeat domain 8 Neighboring gene uncharacterized LOC134479463

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Splice variants of the human ZC3H14 gene generate multiple isoforms of a zinc finger polyadenosine RNA binding protein. Leung SW, et al. Gene, 2009 Jun 15. PMID 19303045, Free PMC Article
    2. The Conserved, Disease-Associated RNA Binding Protein dNab2 Interacts with the Fragile X Protein Ortholog in Drosophila Neurons. Bienkowski RS, et al. Cell Rep, 2017 Aug 8. PMID 28793261, Free PMC Article
    3. Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans. Pak C, et al. Proc Natl Acad Sci U S A, 2011 Jul 26. PMID 21734151, Free PMC Article
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105318

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axon cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 14
    Names
    nuclear protein UKp68
    nuclear protein UKp83/UKp68

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033951.1 → NP_001029123.1  zinc finger CCCH domain-containing protein 14 isoform 1

      See identical proteins and their annotated locations for NP_001029123.1

      Status: PROVISIONAL

      Source sequence(s)
      AB097077
      UniProtKB/Swiss-Prot
      Q7TMD5, Q7TSK6, Q99NC1
      UniProtKB/TrEMBL
      D4A652
      Related
      ENSRNOP00000047580.4, ENSRNOT00000040440.6
      Conserved Domains (1) summary
      pfam14608
      Location:621 → 639
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    2. NM_138920.1 → NP_620275.1  zinc finger CCCH domain-containing protein 14 isoform 2

      See identical proteins and their annotated locations for NP_620275.1

      Status: PROVISIONAL

      Source sequence(s)
      AB032932
      UniProtKB/TrEMBL
      A0A8I6AN22
      Conserved Domains (1) summary
      pfam14608
      Location:551 → 567
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      123736120..123773775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764739.4 → XP_008762961.1  zinc finger CCCH domain-containing protein 14 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1Y3, A0A8I6AN22
      Related
      ENSRNOP00000084418.1
      Conserved Domains (1) summary
      pfam14608
      Location:550 → 566
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    2. XM_039111771.2 → XP_038967699.1  zinc finger CCCH domain-containing protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AN22

    3. XM_008764738.4 → XP_008762960.1  zinc finger CCCH domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      D4A652
      Conserved Domains (1) summary
      pfam14608
      Location:621 → 639
      zf-CCCH_2; RNA-binding, Nab2-type zinc finger

    4. XM_039111768.2 → XP_038967696.1  zinc finger CCCH domain-containing protein 14 isoform X3

      UniProtKB/TrEMBL
      D4A652

    5. XM_039111767.2 → XP_038967695.1  zinc finger CCCH domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      D4A7G0
      Related
      ENSRNOP00000035319.6

    6. XM_039111772.2 → XP_038967700.1  zinc finger CCCH domain-containing protein 14 isoform X6

      Conserved Domains (1) summary
      COG1196
      Location:35 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_008764740.3 → XP_008762962.1  zinc finger CCCH domain-containing protein 14 isoform X8

      UniProtKB/TrEMBL
      A0A0G2K596
      Related
      ENSRNOP00000073344.1
      Conserved Domains (2) summary
      COG1196
      Location:35 → 145
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      COG5084
      Location:179 → 273
      YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]

    8. XM_063261539.1 → XP_063117609.1  zinc finger CCCH domain-containing protein 14 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMD5.1 GenPept UniProtKB/Swiss-Prot:Q7TMD5

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