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    egl-3 Neuroendocrine convertase 2 [ Caenorhabditis elegans ]

    Gene ID: 179412, updated on 23-Nov-2023

    Summary

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    Gene symbol
    egl-3
    Gene description
    Neuroendocrine convertase 2
    Primary source
    WormBase:WBGene00001172
    Locus tag
    CELE_C51E3.7
    See related
    AllianceGenome:WB:WBGene00001172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables FBXO family protein binding activity and serine-type endopeptidase activity. Involved in several processes, including larval feeding behavior; modulation of chemical synaptic transmission; and protein processing. Located in axon. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and uv1. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (10169177..10173753, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene DUF3149 domain-containing protein Neighboring gene Solute carrier family 23 member 2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a key neuropeptide processing enzyme in C. elegans by mass spectrometry. Husson SJ, et al. Commun Agric Appl Biol Sci, 2006. PMID 17191499
    2. Isolation and in situ localization of a cDNA encoding a Kex2-like prohormone convertase in the nematode Caenorhabditis elegans. Gómez-Saladín E, et al. Cell Mol Neurobiol, 1994 Feb. PMID 7954663
    3. Navigational choice between reversal and curve during acidic pH avoidance behavior in Caenorhabditis elegans. Wakabayashi T, et al. BMC Neurosci, 2015 Nov 19. PMID 26584677, Free PMC Article
    4. An AP2 transcription factor is required for a sleep-active neuron to induce sleep-like quiescence in C. elegans. Turek M, et al. Curr Biol, 2013 Nov 18. PMID 24184105
    5. RIC-7 promotes neuropeptide secretion. Hao Y, et al. PLoS Genet, 2012 Jan. PMID 22275875, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data has shown that thermal avoidance behavior of egl-3 and egl-21 mutants was significantly hampered compared to WT(N2) C. elegans.
      Title: EGL-3 and EGL-21 are required to trigger nocifensive response of Caenorhabditis elegans to noxious heat.
    2. Role of PC2/EGL-3 in the processing of FMRFamide-like peptide (FLP) precursors and neuropeptide-like protein (NLP) precursors in nematodes.
      Title: Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables FBXO family protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arg-arg specific dibasic protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in dibasic protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dauer entry IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of dense core granule transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of turning behavior involved in mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neuropeptide processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of acetylcholine secretion, neurotransmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of acetylcholine secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of backward locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of digestive system process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of forward locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of forward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lipid localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of backward locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion involved in locomotory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to mechanical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to serotonin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Neuroendocrine convertase 2
    NP_001023732.1
    • Confirmed by transcript evidence
    NP_001256192.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10169177..10173753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001028561.4 → NP_001023732.1  Neuroendocrine convertase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023732.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E9P883, G5ECN9, Q18772
      Conserved Domains (3) summary
      cd04059
      Location:128 → 423
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:532 → 619
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:29 → 107
      S8_pro-domain; Peptidase S8 pro-domain

    2. NM_001269263.3 → NP_001256192.1  Neuroendocrine convertase 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256192.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5ECN9
      Conserved Domains (3) summary
      cd04059
      Location:3 → 298
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:40 → 302
      Peptidase_S8; Subtilase family
      pfam01483
      Location:407 → 494
      P_proprotein; Proprotein convertase P-domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5ECN9.1

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