hcp-2 HoloCentric chromosome binding Protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: hcp-2
Gene description: HoloCentric chromosome binding Protein
Primary source: WormBase:WBGene00001830
Locus tag: CELE_T06E4.1
See related: AllianceGenome:WB:WBGene00001830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in meiotic spindle organization; nuclear division; and protein localization. Located in kinetochore. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (9645859..9650211)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The C. elegans NudE homolog NUD-2 is dispensable for dynein- and LIS-1-dependent mitotic spindle assembly in the zygote. This facilitates functional characterization of kinetochore-localized NUD-2, which is recruited by the CENP-F-like proteins HCP-1 and HCP-2 independently of RZZ-Spindly and dynein-LIS-1.
Title: NudE regulates dynein at kinetochores but is dispensable for other dynein functions in the C. elegans early embryo.
show that HCP-1 and HCP-2 recently implicated in the spindle assembly checkpoint (SAC) function, do not have identical functions, since hcp-1(RNAi), but not hcp-2(RNAi), enhances the lethality of the spindle assembly checkpoint components mutants
Title: Synthetic lethal interactions identify phenotypic "interologs" of the spindle assembly checkpoint components.
The key role of HCP-1/2 is to target CLASP(CLS-2) to kinetochores to mediate chromosome segregation.
Title: The CENP-F-like proteins HCP-1 and HCP-2 target CLASP to kinetochores to mediate chromosome segregation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T06E4.1 (e-PCR)
- UniSTS:307949

T06E4.3 (e-PCR)
- UniSTS:307951

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of meiotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: HoloCentric chromosome binding Protein

NP_505489.1

Product from WormBase gene class hcp;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

9645859..9650211

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073088.5 → NP_505489.1 HoloCentric chromosome binding Protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_505489.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22257

Conserved Domains (3) summary

COG1196
Location:224 → 1043

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam08192
Location:40 → 204

Peptidase_S64; Peptidase family S64

cl14813
Location:587 → 722

GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)