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    unc-22 Twitchin [ Caenorhabditis elegans ]

    Gene ID: 178135, updated on 11-Apr-2024

    Summary

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    Gene symbol
    unc-22
    Gene description
    Twitchin
    Primary source
    WormBase:WBGene00006759
    Locus tag
    CELE_ZK617.1
    See related
    AllianceGenome:WB:WBGene00006759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including behavioral response to nicotine; positive regulation of sarcomere organization; and protein phosphorylation. Located in A band. Is expressed in body wall musculature; pharyngeal muscle cell; and vulval muscle. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to human TTN (titin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    37
    Sequence:
    Chromosome: IV; NC_003282.8 (11972697..12011007, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class J Neighboring gene pseudo Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Spermatogenesis-defective protein spe-17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autophosphorylation Is a Mechanism of Inhibition in Twitchin Kinase. Williams RM, et al. J Mol Biol, 2018 Mar 16. PMID 29408381
    2. Twitchin kinase inhibits muscle activity. Matsunaga Y, et al. Mol Biol Cell, 2017 Jun 15. PMID 28428253, Free PMC Article
    3. Hsp90 and Physiological Stress Are Linked to Autonomous Transposon Mobility and Heritable Genetic Change in Nematodes. Ryan CP, et al. Genome Biol Evol, 2016 Dec 1. PMID 28082599, Free PMC Article
    4. The importance of being regular: Caenorhabditis elegans and Pristionchus pacificus defecation mutants are hypersusceptible to bacterial pathogens. Rae R, et al. Int J Parasitol, 2012 Jul. PMID 22705203
    5. An introductory bioinformatics exercise to reinforce gene structure and expression and analyze the relationship between gene and protein sequences. Almeida CA, et al. Biochem Mol Biol Educ, 2004 Jul. PMID 21706731

    See all (167) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Twitchin is activated by MAK-1. Twitchin may ba also regulated by the p38 MAP kinase pathway.
      Title: Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of striated muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in A band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in M band IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Twitchin
    NP_001122835.2
    • Partially confirmed by transcript evidence
    NP_001255601.1
    • Partially confirmed by transcript evidence
    NP_001255602.1
    • Partially confirmed by transcript evidence
    NP_001255603.2
    • Partially confirmed by transcript evidence
    NP_001255604.1
    • Partially confirmed by transcript evidence
    NP_001293974.1
    • Partially confirmed by transcript evidence
    NP_001293975.1
    • Partially confirmed by transcript evidence
    NP_502273.2
    • Partially confirmed by transcript evidence
    NP_502274.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11972697..12011007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069872.6 → NP_502273.2  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502273.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23551
      Conserved Domains (10) summary
      cd00096
      Location:5621 → 5690
      Ig; Immunoglobulin domain
      cd05748
      Location:1493 → 1566
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6407 → 6467
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:5942 → 6197
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:5707 → 5789
      IG; Immunoglobulin
      smart00410
      Location:384 → 467
      IG_like; Immunoglobulin like
      cd00063
      Location:4713 → 4806
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:6266 → 6355
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:5939 → 6197
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3555 → 3628
      Ig; Immunoglobulin domain

    2. NM_001268672.3 → NP_001255601.1  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLH2
      Conserved Domains (10) summary
      cd00096
      Location:5709 → 5778
      Ig; Immunoglobulin domain
      cd05748
      Location:1581 → 1654
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6495 → 6555
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:6030 → 6285
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:5795 → 5877
      IG; Immunoglobulin
      smart00410
      Location:384 → 467
      IG_like; Immunoglobulin like
      cd00063
      Location:4801 → 4894
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:6354 → 6443
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:6027 → 6285
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3643 → 3716
      Ig; Immunoglobulin domain

    3. NM_001268673.3 → NP_001255602.1  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255602.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLH3
      Conserved Domains (10) summary
      cd00096
      Location:5630 → 5699
      Ig; Immunoglobulin domain
      cd05748
      Location:1502 → 1575
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6416 → 6476
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:5951 → 6206
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:5716 → 5798
      IG; Immunoglobulin
      smart00410
      Location:384 → 467
      IG_like; Immunoglobulin like
      cd00063
      Location:4722 → 4815
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:6275 → 6364
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:5948 → 6206
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3564 → 3637
      Ig; Immunoglobulin domain

    4. NM_001307046.3 → NP_001293975.1  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293975.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACT3
      Conserved Domains (10) summary
      cd00096
      Location:5915 → 5984
      Ig; Immunoglobulin domain
      cd05748
      Location:1787 → 1860
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6701 → 6761
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:6236 → 6491
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:6001 → 6083
      IG; Immunoglobulin
      smart00410
      Location:384 → 467
      IG_like; Immunoglobulin like
      cd00063
      Location:5007 → 5100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:6560 → 6649
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:6233 → 6491
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3849 → 3922
      Ig; Immunoglobulin domain

    5. NM_001307045.3 → NP_001293974.1  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293974.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AE24
      Conserved Domains (10) summary
      cd00096
      Location:5924 → 5993
      Ig; Immunoglobulin domain
      cd05748
      Location:1796 → 1869
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6710 → 6770
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:6245 → 6500
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:6010 → 6092
      IG; Immunoglobulin
      smart00410
      Location:384 → 467
      IG_like; Immunoglobulin like
      cd00063
      Location:5016 → 5109
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:6569 → 6658
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:6242 → 6500
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3858 → 3931
      Ig; Immunoglobulin domain

    6. NM_069873.6 → NP_502274.2  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502274.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A3RMU0, D3YT57, D3YT58, Q23020, Q23550, Q23551, Q27232, Q7JN85
      Conserved Domains (10) summary
      cd00096
      Location:5940 → 6009
      Ig; Immunoglobulin domain
      cd05748
      Location:1812 → 1885
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6726 → 6786
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:6261 → 6516
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:6026 → 6108
      IG; Immunoglobulin
      smart00410
      Location:384 → 467
      IG_like; Immunoglobulin like
      cd00063
      Location:5032 → 5125
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:6585 → 6674
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:6258 → 6516
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3874 → 3947
      Ig; Immunoglobulin domain

    7. NM_001268674.4 → NP_001255603.2  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255603.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23551
      Conserved Domains (10) summary
      cd00096
      Location:5234 → 5303
      Ig; Immunoglobulin domain
      cd05748
      Location:1106 → 1179
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6020 → 6080
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:5555 → 5810
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:5320 → 5402
      IG; Immunoglobulin
      smart00410
      Location:3752 → 3826
      IG_like; Immunoglobulin like
      cd00063
      Location:4326 → 4419
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:5879 → 5968
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:5552 → 5810
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3168 → 3241
      Ig; Immunoglobulin domain

    8. NM_001129363.4 → NP_001122835.2  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122835.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23551
      Conserved Domains (10) summary
      cd00096
      Location:5401 → 5470
      Ig; Immunoglobulin domain
      cd05748
      Location:1273 → 1346
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6187 → 6247
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:5722 → 5977
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:5487 → 5569
      IG; Immunoglobulin
      smart00410
      Location:3919 → 3993
      IG_like; Immunoglobulin like
      cd00063
      Location:4493 → 4586
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:6046 → 6135
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:5719 → 5977
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3335 → 3408
      Ig; Immunoglobulin domain

    9. NM_001268675.3 → NP_001255604.1  Twitchin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23551
      Conserved Domains (10) summary
      cd00096
      Location:5217 → 5286
      Ig; Immunoglobulin domain
      cd05748
      Location:1089 → 1162
      Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
      smart00408
      Location:6003 → 6063
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:5538 → 5793
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00409
      Location:5303 → 5385
      IG; Immunoglobulin
      smart00410
      Location:3735 → 3809
      IG_like; Immunoglobulin like
      cd00063
      Location:4309 → 4402
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:5862 → 5951
      I-set; Immunoglobulin I-set domain
      cd14114
      Location:5535 → 5793
      STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
      cl11960
      Location:3151 → 3224
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23551.3

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