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    cdh-5 Cadherin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177671, updated on 23-Nov-2023

    Summary

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    Gene symbol
    cdh-5
    Gene description
    Cadherin domain-containing protein
    Primary source
    WormBase:WBGene00000397
    Locus tag
    CELE_F08B4.2
    See related
    AllianceGenome:WB:WBGene00000397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    23
    Sequence:
    Chromosome: IV; NC_003282.8 (8668935..8676619)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene Secreted protein Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cadherin superfamily. Pettitt J. WormBook, 2005 Dec 29. PMID 18050421, Free PMC Article
    2. Cell adhesion receptors in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090591
    3. Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster. Hill E, et al. J Mol Biol, 2001 Feb 2. PMID 11162110
    4. UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. Ziel JW, et al. Nat Cell Biol, 2009 Feb. PMID 19098902, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cadherin domain-containing protein
    NP_001294026.1
    • Confirmed by transcript evidence
    NP_001343640.1
    • Confirmed by transcript evidence
    NP_001343703.1
    • Confirmed by transcript evidence
    NP_501487.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8668935..8676619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356929.4 → NP_001343640.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19194
      Conserved Domains (3) summary
      cd11304
      Location:812 → 906
      Cadherin_repeat; Cadherin tandem repeat domain
      PRK11633
      Location:596 → 701
      PRK11633; cell division protein DedD; Provisional
      cl26464
      Location:447 → 728
      Atrophin-1; Atrophin-1 family

    2. NM_001307097.4 → NP_001294026.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294026.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M8R9
      Conserved Domains (2) summary
      cd11304
      Location:669 → 763
      Cadherin_repeat; Cadherin tandem repeat domain
      NF033839
      Location:462 → 583
      PspC_subgroup_2; pneumococcal surface protein PspC, LPXTG-anchored form

    3. NM_069086.6 → NP_501487.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501487.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZC7
      Conserved Domains (1) summary
      cd11304
      Location:669 → 763
      Cadherin_repeat; Cadherin tandem repeat domain

    4. NM_001356930.4 → NP_001343703.1  Cadherin domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5M5L3
      Conserved Domains (3) summary
      cd11304
      Location:812 → 906
      Cadherin_repeat; Cadherin tandem repeat domain
      PRK11633
      Location:596 → 701
      PRK11633; cell division protein DedD; Provisional
      cl26464
      Location:447 → 728
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein
    Heading Accession and Version

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