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    isp-1 Cytochrome b-c1 complex subunit Rieske, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 177609, updated on 23-Nov-2023

    Summary

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    Gene symbol
    isp-1
    Gene description
    Cytochrome b-c1 complex subunit Rieske, mitochondrial
    Primary source
    WormBase:WBGene00002162
    Locus tag
    CELE_F42G8.12
    See related
    AllianceGenome:WB:WBGene00002162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity. Involved in several processes, including mitochondrial electron transport, ubiquinol to cytochrome c; regulation of gene expression; and regulation of protein phosphorylation. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be integral component of membrane. Predicted to be part of mitochondrial respiratory chain complex III. Is expressed in several structures, including enteric muscle; intestine; nervous system; rectal epithelium; and reproductive system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (8134016..8136055, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Molybdopterin-synthase sulfurtransferase Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Interactor with SLO-1 Neighboring gene Mitogen-activated protein kinase pmk-3;Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in mitochondrial complex III uniquely affect complex I in Caenorhabditis elegans. Suthammarak W, et al. J Biol Chem, 2010 Dec 24. PMID 20971856, Free PMC Article
    2. New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans. Jafari G, et al. Worm, 2016 Apr-Jun. PMID 27383074, Free PMC Article
    3. Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein. Jafari G, et al. Proc Natl Acad Sci U S A, 2015 Nov 10. PMID 26504246, Free PMC Article
    4. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. Yang W, et al. PLoS Biol, 2010 Dec 7. PMID 21151885, Free PMC Article
    5. A role for p53 in mitochondrial stress response control of longevity in C. elegans. Torgovnick A, et al. Exp Gerontol, 2010 Aug. PMID 20172019

    See all (104) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gating and control processes influence the function of ISP-1 in mediating pleiotropic phenotypes including developmental rate, movement, sensitivity to stress, and longevity.
      Title: Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.
    2. stress response, and/or fecundity of isp-1(qm150) Mit mutants relative to wild-type animalsstress response, and/or fecundity of isp-1(qm150) Mit mutants relative to wild-type animals
      Title: TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.
    3. ROS production by mitochondrial mutants and found that isp-1 and nuo-6 mutants have increased generation of the superoxide anion but not increased levels of other ROS and that this increase is necessary and sufficient for longevity.
      Title: A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
    4. found that the lifespan increase induced by nuo-6(RNAi) is fully additive to that induced by isp-1(qm150), and the increase induced by isp-1(RNAi) is fully additive to that induced by nuo-6(qm200)
      Title: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquinol-cytochrome-c reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cytochrome b-c1 complex subunit Rieske, mitochondrial
    NP_501361.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8134016..8136055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068960.6 → NP_501361.1  Cytochrome b-c1 complex subunit Rieske, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501361.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44512
      Conserved Domains (3) summary
      cd03470
      Location:152 → 274
      Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
      TIGR01416
      Location:109 → 274
      Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
      pfam02921
      Location:80 → 146
      UCR_TM; Ubiquinol cytochrome reductase transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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