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    tpk-1 thiamine pyrophosphokinase 1 [ Caenorhabditis elegans ]

    Gene ID: 176258, updated on 23-Nov-2023

    Summary

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    Gene symbol
    tpk-1
    Gene description
    thiamine pyrophosphokinase 1
    Primary source
    WormBase:WBGene00014027
    Locus tag
    CELE_ZK637.9
    See related
    AllianceGenome:WB:WBGene00014027
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Is expressed in body wall musculature and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (8912144..8913632)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene V-type proton ATPase 116 kDa subunit a 1 Neighboring gene ncRNA Neighboring gene putative glutathione reductase 2 Neighboring gene M-phase inducer phosphatase cdc-25.3 Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thiamine pyrophosphate biosynthesis and transport in the nematode Caenorhabditis elegans. de Jong L, et al. Genetics, 2004 Oct. PMID 15514058, Free PMC Article
    2. Decreased energy metabolism extends life span in Caenorhabditis elegans without reducing oxidative damage. Van Raamsdonk JM, et al. Genetics, 2010 Jun. PMID 20382831, Free PMC Article
    3. A metabolic signature for long life in the Caenorhabditis elegans Mit mutants. Butler JA, et al. Aging Cell, 2013 Feb. PMID 23173729, Free PMC Article
    4. Longevity manipulations differentially affect serotonin/dopamine level and behavioral deterioration in aging Caenorhabditis elegans. Yin JA, et al. J Neurosci, 2014 Mar 12. PMID 24623772, Free PMC Article
    5. TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Khan MH, et al. Aging (Albany NY), 2013 Oct. PMID 24107417, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. stress response, and/or fecundity of isp-1(qm150) Mit mutants relative to wild-type animals
      Title: TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thiamine pyrophosphokinase 1
    NP_001023024.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8912144..8913632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027853.2 → NP_001023024.1  thiamine pyrophosphokinase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023024.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30636, Q5FC86, Q6R5A6
      Conserved Domains (2) summary
      cd07995
      Location:18 → 232
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:33 → 233
      PLN02714; thiamin pyrophosphokinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30636.3

    Gene LinkOut

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