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    ZK686.3 putative dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 [ Caenorhabditis elegans ]

    Gene ID: 176089, updated on 23-Nov-2023

    Summary

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    Gene symbol
    ZK686.3
    Gene description
    putative dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
    Primary source
    WormBase:WBGene00022793
    Locus tag
    CELE_ZK686.3
    See related
    AllianceGenome:WB:WBGene00022793
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia; autosomal recessive non-syndromic intellectual disability; congenital disorder of glycosylation Icc; and non-syndromic X-linked intellectual disability. Orthologous to human MAGT1 (magnesium transporter 1) and TUSC3 (tumor suppressor candidate 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (7767573..7769063, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Putative ATP-dependent RNA helicase ZK686.2 Neighboring gene Putative zinc finger protein ZK686.5 Neighboring gene Putative zinc finger matrin-type protein snu-23 Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    2. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oligosaccharyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3
    NP_498691.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7767573..7769063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066290.7 → NP_498691.1  putative dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498691.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34669
      Conserved Domains (1) summary
      pfam04756
      Location:147 → 313
      OST3_OST6; OST3 / OST6 family
    Nucleotide Protein
    Heading Accession and Version

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