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    Ppp3cc protein phosphatase 3 catalytic subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171378, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ppp3ccprovided by RGD
    Official Full Name
    protein phosphatase 3 catalytic subunit gammaprovided by RGD
    Primary source
    RGD:621616
    See related
    Ensembl:ENSRNOG00000009745 AllianceGenome:RGD:621616
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in brain development and positive regulation of synaptic vesicle endocytosis. Located in presynapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 130.3), Heart (RPKM 120.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    15p11
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (51699586..51771763, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45289917..45362012, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (51896427..51968075, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482142 Neighboring gene PDZ and LIM domain 2 Neighboring gene sorbin and SH3 domain containing 3 Neighboring gene mitochondrial pyruvate carrier 1-like Neighboring gene solute carrier family 39 member 14 Neighboring gene histone deacetylase 1-like Neighboring gene piwi-like RNA-mediated gene silencing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task. Havekes R, et al. Learn Mem, 2006 Nov-Dec. PMID 17101875, Free PMC Article
    2. Calcineurin is not involved in some mitochondrial enzyme adaptations to endurance exercise training in rat skeletal muscle. Terada S, et al. Eur J Appl Physiol, 2003 Sep. PMID 12856186
    3. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Gerber DJ, et al. Proc Natl Acad Sci U S A, 2003 Jul 22. PMID 12851458, Free PMC Article
    4. Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes. Fiedler B, et al. Proc Natl Acad Sci U S A, 2002 Aug 20. PMID 12177418, Free PMC Article
    5. Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development. Eastwood SL, et al. Eur J Neurosci, 2005 Dec. PMID 16367768

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNAi-mediated knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in cultured rat hippocampal neurons.
      Title: Calcineurin Aγ is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis.
    2. Findings show memory formation is accompanied by reduced CaN activity, whereas adapting to changes in a familiar environment is accompanied by restored CaN activity. Reversal training selectively affects hippocampal CA3 and CA1 regions.
      Title: Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task.
    3. PKG I inhibits cardiac myocyte hypertrophy by targeting the calcineurin-NFAT signaling pathway
      Title: Inhibition of calcineurin-NFAT hypertrophy signaling by cGMP-dependent protein kinase type I in cardiac myocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in calcineurin-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within penetration of zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of calcineurin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm mitochondrial sheath ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
    Names
    protein phosphatase 3, catalytic subunit, gamma isozyme
    NP_599194.1
    XP_008769035.1
    XP_008769036.1
    XP_038948901.1
    XP_038948902.1
    XP_038948903.1
    XP_038948904.1
    XP_063130022.1
    XP_063130023.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134367.1 → NP_599194.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

      See identical proteins and their annotated locations for NP_599194.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079027
      UniProtKB/TrEMBL
      A0A8J8XJJ2, Q6AYJ0
      Related
      ENSRNOP00000095864.1, ENSRNOT00000100817.1
      Conserved Domains (2) summary
      smart00156
      Location:54 → 325
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:37 → 341
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      51699586..51771763 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092976.2 → XP_038948904.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X6

      UniProtKB/TrEMBL
      A0A8J8XJJ2
      Conserved Domains (1) summary
      cd07416
      Location:37 → 341
      MPP_PP2B; PP2B, metallophosphatase domain

    2. XM_039092973.2 → XP_038948901.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2

      UniProtKB/TrEMBL
      A0A8J8XJJ2
      Conserved Domains (1) summary
      cd07416
      Location:37 → 341
      MPP_PP2B; PP2B, metallophosphatase domain

    3. XM_008770814.4 → XP_008769036.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4

      See identical proteins and their annotated locations for XP_008769036.1

      UniProtKB/TrEMBL
      A0A8J8XJJ2, E2CWF1
      Related
      ENSRNOP00000069433.1
      Conserved Domains (2) summary
      smart00156
      Location:54 → 325
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:37 → 341
      MPP_PP2B; PP2B, metallophosphatase domain

    4. XM_039092974.2 → XP_038948902.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3

      UniProtKB/TrEMBL
      A0A0G2K820, A0A8J8XJJ2
      Related
      ENSRNOP00000074438.2
      Conserved Domains (1) summary
      cd07416
      Location:37 → 341
      MPP_PP2B; PP2B, metallophosphatase domain

    5. XM_008770813.4 → XP_008769035.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1

      See identical proteins and their annotated locations for XP_008769035.1

      UniProtKB/TrEMBL
      A0A8J8XJJ2, E2CWF0, F1M7P9
      Related
      ENSRNOP00000075488.2
      Conserved Domains (2) summary
      smart00156
      Location:54 → 325
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:37 → 341
      MPP_PP2B; PP2B, metallophosphatase domain

    6. XM_039092975.2 → XP_038948903.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

      UniProtKB/TrEMBL
      A0A8J8XJJ2
      Conserved Domains (1) summary
      cd07416
      Location:2 → 303
      MPP_PP2B; PP2B, metallophosphatase domain

    7. XM_063273952.1 → XP_063130022.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5

    8. XM_063273953.1 → XP_063130023.1  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

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