Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp3a11provided by MGI
Official Full Name: cytochrome P450, family 3, subfamily a, polypeptide 11provided by MGI
Primary source: MGI:MGI:88609
See related: Ensembl:ENSMUSG00000056035 AllianceGenome:MGI:88609
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pcn; Cyp3a; IIIAm1
Summary: Enables monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4) and CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward liver adult (RPKM 331.5) See more
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Genomic context

Location:: 5 G2; 5 85.17 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (145791417..145816664, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (145854607..145879854, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study.
Title: Human gut microbiota influences drug-metabolizing enzyme hepatic Cyp3a: A human flora-associated mice study.
Here we unravel a critical role of Bmal1 for circadian clock-controlled Cyp3a11 expression and xenobiotic metabolism. Bmal1 connects circadian clock and Cyp3a11 metabolism, thereby impacting drug detoxification as a function of daily time.
Title: Bmal1 regulates circadian expression of cytochrome P450 3a11 and drug metabolism in mice.
Its mRNA expression is decreased by the high level of MRSA, but the low level of MRSA increased its expression.
Title: Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.
In het mice, RIF had no effect on plasma lipids composition, CYP27A1 activity, and atherosclerotic plaque development, despite a reduction in cholesterol absorption. In conclusion, the antiatherogenic effect of Cyp3a11 induction by RIF was also dependent on Cyp27a1 expression.
Title: Sterol 27-hydroxylase gene dosage and the antiatherosclerotic effect of Rifampicin in mice.
lack of Cyp3a has a positive effect on acclimation to a high-fat diet in females as it improves weight gain, glucose response and ketosis.
Title: High fat diet induced obesity is mitigated in Cyp3a-null female mice.
the interactions of quercetin and naringenin with CYP1A and CYP3A in mice liver were not affected by the levels of persistent organic pollutants exposure.
Title: Effect of Naringenin, Quercetin, and Sesamin on Xenobiotica-Metabolizing CYP1A and CYP3A in Mice Offspring after Maternal Exposure to Persistent Organic Pollutants.
Cyp3a is a major determinant of systemic levels of testosterone in mice.
Title: Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.
Diabetes mellitus caused a decrease in the activity of Cyp3a11-mediated testosterone-6beta-hydroxylation, but no change in the activity of Cyp3a11-mediated midazolam 1-hydroxylation and an increase in the activity of UGT1a9-mediated propofol O-glucuronidation in db/db mice
Title: Cyp3a11-mediated testosterone-6β-hydroxylation decreased, while UGT1a9-mediated propofol O-glucuronidation increased, in mice with diabetes mellitus.
Schisandrol B protects against APAP-induced liver injury, potentially through inhibition of CYP2E1/3A11-mediated APAP bioactivation and regulation of the p53, p21, CCND1, PCNA, and BCL-2 to promote liver regeneration.
Title: Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.
Data (including data from studies using recombinant enzymes/knockout mice) suggest that Cyp3a/Cyp3a11 is primary enzyme in liver microsomes contributing to formation of aldehydes during metabolic inactivation of gefitinib, an antineoplastic agent.
Title: Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Markers

D5Mit409 (e-PCR), detects polymorphism
- UniSTS:130565

X60452 (e-PCR)
- UniSTS:179319

AI256190 (e-PCR)
- UniSTS:179322

Cyp3a11 (e-PCR), detects polymorphism
- UniSTS:463002

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables demethylase activity	ISO Inferred from Sequence Orthology more info
enables estrogen 16-alpha-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 6-beta-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 6-beta-hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alkaloid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in oxidative demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidative demethylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 3A11

Names: CYPIIIA11; cytochrome P-450IIIAM1; cytochrome P-450UT; cytochrome P450, steroid inducible 3a11; steroid inducible

NP_031844.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.