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    Ankrd12 ankyrin repeat domain 12 [ Mus musculus (house mouse) ]

    Gene ID: 106585, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ankrd12provided by MGI
    Official Full Name
    ankyrin repeat domain 12provided by MGI
    Primary source
    MGI:MGI:1914357
    See related
    Ensembl:ENSMUSG00000034647 AllianceGenome:MGI:1914357
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAC-1; ANCO-2; mKIAA0874; 2900001A12Rik
    Summary
    Predicted to be located in cytosol and nucleoplasm. Orthologous to human ANKRD12 (ankyrin repeat domain 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 6.8), whole brain E14.5 (RPKM 5.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 E1.1; 17 35.26 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66272698..66386242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (65965703..66078804, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35550 Neighboring gene STARR-seq mESC enhancer starr_43037 Neighboring gene twisted gastrulation BMP signaling modulator 1 Neighboring gene STARR-positive B cell enhancer ABC_E8691 Neighboring gene STARR-seq mESC enhancer starr_43040 Neighboring gene STARR-positive B cell enhancer ABC_E10965 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V2 Neighboring gene predicted gene, 23264 Neighboring gene STARR-seq mESC enhancer starr_43041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66456304-66456487 Neighboring gene STARR-positive B cell enhancer ABC_E10966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:66460812-66460921 Neighboring gene WASH complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of novel ARF binding proteins by two-hybrid screening. Tompkins V, et al. Cell Cycle, 2006 Mar. PMID 16582619
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025572.1 → NP_001020743.1  ankyrin repeat domain-containing protein 12

      See identical proteins and their annotated locations for NP_001020743.1

      Status: VALIDATED

      Source sequence(s)
      AC119957, AC121299, AK122392, BC023046, CF553222, CF907970
      Consensus CDS
      CCDS28943.1
      UniProtKB/TrEMBL
      G5E893
      Related
      ENSMUSP00000039035.6, ENSMUST00000038116.13
      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      66272698..66386242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523393.5 → XP_006523456.1  ankyrin repeat domain-containing protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006523456.1

      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_006523397.5 → XP_006523460.1  ankyrin repeat domain-containing protein 12 isoform X3

      Conserved Domains (4) summary
      PTZ00121
      Location:359 → 1142
      PTZ00121; MAEBL; Provisional
      COG0666
      Location:55 → 253
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:161 → 192
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:166 → 254
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_030249419.2 → XP_030105279.1  ankyrin repeat domain-containing protein 12 isoform X5

      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006523396.5 → XP_006523459.1  ankyrin repeat domain-containing protein 12 isoform X2

      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_036160243.1 → XP_036016136.1  ankyrin repeat domain-containing protein 12 isoform X1

      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_036160245.1 → XP_036016138.1  ankyrin repeat domain-containing protein 12 isoform X6

      Conserved Domains (3) summary
      PTZ00121
      Location:335 → 1118
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:137 → 168
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:142 → 230
      Ank_2; Ankyrin repeats (3 copies)

    7. XM_030249420.2 → XP_030105280.1  ankyrin repeat domain-containing protein 12 isoform X8

      Conserved Domains (1) summary
      PTZ00121
      Location:89 → 872
      PTZ00121; MAEBL; Provisional

    8. XM_006523399.5 → XP_006523462.1  ankyrin repeat domain-containing protein 12 isoform X7

      Conserved Domains (4) summary
      PTZ00121
      Location:359 → 1142
      PTZ00121; MAEBL; Provisional
      COG0666
      Location:55 → 253
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:161 → 192
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:166 → 254
      Ank_2; Ankyrin repeats (3 copies)

    9. XM_006523395.4 → XP_006523458.1  ankyrin repeat domain-containing protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006523458.1

      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)

    10. XM_030249418.2 → XP_030105278.1  ankyrin repeat domain-containing protein 12 isoform X3

      Conserved Domains (4) summary
      PTZ00121
      Location:359 → 1142
      PTZ00121; MAEBL; Provisional
      COG0666
      Location:55 → 253
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:161 → 192
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:166 → 254
      Ank_2; Ankyrin repeats (3 copies)

    11. XM_006523394.5 → XP_006523457.1  ankyrin repeat domain-containing protein 12 isoform X1

      See identical proteins and their annotated locations for XP_006523457.1

      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)

    12. XM_030249417.1 → XP_030105277.1  ankyrin repeat domain-containing protein 12 isoform X3

      Conserved Domains (4) summary
      PTZ00121
      Location:359 → 1142
      PTZ00121; MAEBL; Provisional
      COG0666
      Location:55 → 253
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:161 → 192
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:166 → 254
      Ank_2; Ankyrin repeats (3 copies)

    13. XM_036160246.1 → XP_036016139.1  ankyrin repeat domain-containing protein 12 isoform X9

      Conserved Domains (1) summary
      PTZ00121
      Location:80 → 863
      PTZ00121; MAEBL; Provisional

    14. XM_036160244.1 → XP_036016137.1  ankyrin repeat domain-containing protein 12 isoform X4

      UniProtKB/TrEMBL
      G5E893
      Conserved Domains (3) summary
      PTZ00121
      Location:382 → 1165
      PTZ00121; MAEBL; Provisional
      sd00045
      Location:184 → 215
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:189 → 277
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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