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    Ndufb1 NADH:ubiquinone oxidoreductase subunit B1 [ Mus musculus (house mouse) ]

    Gene ID: 102631912, updated on 10-Mar-2024

    Summary

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    Official Symbol
    Ndufb1provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B1provided by MGI
    Primary source
    MGI:MGI:3780865
    See related
    Ensembl:ENSMUSG00000113902 AllianceGenome:MGI:3780865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm2695; CI-MNLL; 100040297; Ndufb1-ps
    Summary
    Predicted to enable NADH dehydrogenase activity. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 23.3), bladder adult (RPKM 22.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 E; 12 51.33 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101934355..101941997, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101968096..101975738, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene thyroid hormone receptor interactor 11 Neighboring gene predicted gene, 20036 Neighboring gene STARR-positive B cell enhancer ABC_E1452 Neighboring gene ataxin 3 Neighboring gene STARR-seq mESC enhancer starr_33093 Neighboring gene cleavage and polyadenylation specific factor 2 Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 Neighboring gene U3B small nuclear RNA pseudogene 3 Neighboring gene predicted gene, 25203 Neighboring gene Ras and Rab interactor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes. Signes A, et al. Essays Biochem, 2018 Jul 20. PMID 30030361, Free PMC Article
    2. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
    Names
    Complex I-MNLL
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
    NADH-ubiquinone oxidoreductase MNLL subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378525.1 → NP_001365454.1  nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

      Status: VALIDATED

      Source sequence(s)
      AA450698, AI646380
      UniProtKB/Swiss-Prot
      P0DN34
      Related
      ENSMUSP00000159138.2, ENSMUST00000221422.2
      Conserved Domains (1) summary
      pfam08040
      Location:1 → 57
      NADH_oxidored; MNLL subunit

    2. NM_001378527.1 → NP_001365456.1  nADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

      Status: VALIDATED

      Source sequence(s)
      AI646380, BX525811
      UniProtKB/Swiss-Prot
      P0DN34
      Related
      ENSMUSP00000159028.2, ENSMUST00000221191.2
      Conserved Domains (1) summary
      pfam08040
      Location:1 → 57
      NADH_oxidored; MNLL subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      101934355..101941997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DN34.1 GenPept UniProtKB/Swiss-Prot:P0DN34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.