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    cfb complement factor B [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100491419, updated on 25-Jan-2024

    Summary

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    Official Symbol
    cfbprovided by Xenbase
    Official Full Name
    complement factor Bprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-479361
    See related
    Ensembl:ENSXETG00000039379
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    bfd; gbg; cfab; pbf2; ahus4; fbl12
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    Genomic context

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    Location:
    chromosome: 8
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (74106797..74143733)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (53744892..53777706, complement)

    Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene complement C2 Neighboring gene negative elongation factor complex member E Neighboring gene SKI2 subunit of superkiller complex Neighboring gene ATPase H+ transporting V1 subunit G2 Neighboring gene neuraminidase 1 (lysosomal sialidase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within complement activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within complement activation, alternative pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complement factor B
    Names
    properdin factor B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      74106797..74143733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031891487.1 → XP_031747347.1  complement factor B

      UniProtKB/TrEMBL
      A0A6I8S693, A0A803JRJ8
      Related
      ENSXETP00000088709.2, ENSXETT00000100966.2
      Conserved Domains (3) summary
      PHA02927
      Location:35 → 195
      PHA02927; secreted complement-binding protein; Provisional
      cd00190
      Location:474 → 732
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      cd01470
      Location:240 → 442
      vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    Nucleotide Protein Strain
    Heading Accession and Version

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