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    grm5b glutamate receptor, metabotropic 5b [ Danio rerio (zebrafish) ]

    Gene ID: 100332913, updated on 11-Apr-2024

    Summary

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    Official Symbol
    grm5bprovided by ZNC
    Official Full Name
    glutamate receptor, metabotropic 5bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090821-6
    See related
    Ensembl:ENSDARG00000102067 AllianceGenome:ZFIN:ZDB-GENE-090821-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    grm5a
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in brain and retinal inner nuclear layer. Orthologous to human GRM5 (glutamate metabotropic receptor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See grm5b in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (43656207..43768776, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (43540172..43653274)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene RAB38a, member RAS oncogene family Neighboring gene cathepsin C Neighboring gene tyrosinase Neighboring gene NADPH oxidase 4 Neighboring gene histone H3.v1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogeny and expression divergence of metabotropic glutamate receptor genes in the brain of zebrafish (Danio rerio). Haug MF, et al. J Comp Neurol, 2013 May 1. PMID 23047810
    2. Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. Huang YY, et al. PLoS One, 2012. PMID 22523578, Free PMC Article
    3. Rapid effects of estradiol and its receptor agonists on object recognition and object placement in adult male zebrafish. Naderi M, et al. Behav Brain Res, 2020 Apr 20. PMID 32004591
    4. Chronic exposure to environmentally relevant concentrations of bisphenol S differentially affects cognitive behaviors in adult female zebrafish. Naderi M, et al. Environ Pollut, 2020 Jun. PMID 32045791
    5. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    metabotropic glutamate receptor 5b
    Names
    mglur5b
    zmp:0000000769

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302238.1 → NP_001289167.1  metabotropic glutamate receptor 5b precursor

      See identical proteins and their annotated locations for NP_001289167.1

      Status: PROVISIONAL

      Source sequence(s)
      KF234088
      UniProtKB/TrEMBL
      U3N5Y5
      Related
      ENSDARP00000131878.1, ENSDART00000170398.2
      Conserved Domains (5) summary
      cd06374
      Location:27 → 501
      PBP1_mGluR_groupI; Ligand binding domain of the group I metabotropic glutamate receptor
      pfam00003
      Location:595 → 828
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:68 → 476
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:513 → 561
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      pfam10606
      Location:1144 → 1195
      GluR_Homer-bdg; Homer-binding domain of metabotropic glutamate receptor

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      43656207..43768776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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