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    Hexd hexosaminidase D [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100216475, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Hexdprovided by RGD
    Official Full Name
    hexosaminidase Dprovided by RGD
    Primary source
    RGD:2302323
    See related
    Ensembl:ENSRNOG00000036667 AllianceGenome:RGD:2302323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hexdc
    Summary
    Predicted to enable beta-N-acetylhexosaminidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in cytoplasm; extracellular vesicle; and nucleus. Orthologous to human HEXD (hexosaminidase D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 164.2), Spleen (RPKM 114.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q32.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (106978426..107002252)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106479781..106498799)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110406431..110425042)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene urotensin 2 receptor Neighboring gene 2-oxoglutarate and iron-dependent oxygenase domain containing 3 Neighboring gene small nucleolar RNA SNORA26 Neighboring gene cytochrome b-245 chaperone 1 Neighboring gene phosphoglycerate mutase 1, pseudogene 1 Neighboring gene nuclear prelamin A recognition factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanism of Human Nucleocytoplasmic Hexosaminidase D. Alteen MG, et al. Biochemistry, 2016 May 17. PMID 27149221, Free PMC Article
    2. The recently identified hexosaminidase D enzyme substantially contributes to the elevated hexosaminidase activity in rheumatoid arthritis. Pásztói M, et al. Immunol Lett, 2013 Jan. PMID 23099419
    3. Mammalian cells contain a second nucleocytoplasmic hexosaminidase. Gutternigg M, et al. Biochem J, 2009 Apr 1. PMID 19040401, Free PMC Article
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyl-beta-D-galactosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-N-acetylhexosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hexosaminidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hexosaminidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    hexosaminidase D
    Names
    hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing
    hexosaminidase D, catalytic domain containing
    NP_001136034.2
    XP_038940913.1
    XP_063124301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142562.2 → NP_001136034.2  hexosaminidase D

      See identical proteins and their annotated locations for NP_001136034.2

      Status: VALIDATED

      Source sequence(s)
      BC158670, CR464043, DN931298
      UniProtKB/TrEMBL
      B0BN37, F1LR76
      Related
      ENSRNOP00000051807.2, ENSRNOT00000054924.4
      Conserved Domains (1) summary
      cd06565
      Location:9 → 323
      GH20_GcnA-like; Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      106978426..107002252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268231.1 → XP_063124301.1  hexosaminidase D isoform X1

      UniProtKB/TrEMBL
      F1LR76

    2. XM_039084985.2 → XP_038940913.1  hexosaminidase D isoform X2

      Conserved Domains (1) summary
      cl02948
      Location:1 → 195
      GH20_hexosaminidase; Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides. ...

    RNA

    1. XR_010055109.1 RNA Sequence

    2. XR_005489664.2 RNA Sequence

    3. XR_005489666.2 RNA Sequence

    4. XR_005489663.2 RNA Sequence

    5. XR_005489665.2 RNA Sequence

    6. XR_005489655.2 RNA Sequence

    7. XR_010055105.1 RNA Sequence

    8. XR_010055104.1 RNA Sequence

    9. XR_005489660.2 RNA Sequence

    10. XR_010055106.1 RNA Sequence

    11. XR_005489659.2 RNA Sequence

    12. XR_010055103.1 RNA Sequence

    13. XR_005489657.2 RNA Sequence

    14. XR_005489667.2 RNA Sequence

    15. XR_005489656.2 RNA Sequence

    16. XR_010055108.1 RNA Sequence

    17. XR_005489669.2 RNA Sequence

    18. XR_010055107.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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