uqcc6 ubiquinol-cytochrome c reductase complex assembly factor 6 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uqcc6provided by ZNC
Official Full Name: ubiquinol-cytochrome c reductase complex assembly factor 6provided by ZNC
Primary source: ZFIN:ZDB-GENE-100427-3
See related: Ensembl:ENSDARG00000045797 AllianceGenome:ZFIN:ZDB-GENE-100427-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: brawnin; gb:cn833218; si:ch211-68a17.7
Summary: Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in cardiac muscle and skeletal muscle. Orthologous to human C12orf73 (chromosome 12 open reading frame 73). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (18951554..18953318, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (18853603..18855367, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrate that Brawnin, a 71 a.a. peptide encoded by C12orf73, is essential for respiratory chain complex III (CIII) assembly. In zebrafish, Brawnin deletion causes complete CIII loss, resulting in severe growth retardation, lactic acidosis and early death. Findings demonstrate that BRAWNIN is essential for vertebrate oxidative phosphorylation.
Title: Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in mitochondrial cytochrome c oxidase assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex III assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial respiratory chain complex III assembly	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex III assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial respiratory chain complex III assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: ubiquinol-cytochrome-c reductase complex assembly factor 6

Names: protein brawnin; uncharacterized protein C12orf73 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001135573.2 → NP_001129045.1 ubiquinol-cytochrome-c reductase complex assembly factor 6

Status: VALIDATED

Source sequence(s)

CR391963, EH448142

UniProtKB/Swiss-Prot

E7EXZ6

Related

ENSDARP00000129487.1, ENSDART00000155927.2

Conserved Domains (1) summary

pfam14990
Location:1 → 46

DUF4516; Domain of unknown function (DUF4516)