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    Tedc2 tubulin epsilon and delta complex 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100158225, updated on 8-Mar-2024

    Summary

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    Official Symbol
    Tedc2provided by RGD
    Official Full Name
    tubulin epsilon and delta complex 2provided by RGD
    Primary source
    RGD:2293499
    See related
    Ensembl:ENSRNOG00000007436 AllianceGenome:RGD:2293499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in positive regulation of smoothened signaling pathway. Predicted to be located in centriole and cilium. Orthologous to human TEDC2 (tubulin epsilon and delta complex 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 25.9), Spleen (RPKM 24.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13750586..13755775, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13246032..13251196, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13586852..13591938, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 24 Neighboring gene uncharacterized LOC102551327 Neighboring gene netrin 3 Neighboring gene cyclin F Neighboring gene ATP-binding cassette, subfamily A (ABC1), member 17 Neighboring gene uncharacterized LOC134480760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188077

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tubulin epsilon and delta complex protein 2
    Names
    uncharacterized protein C16orf59 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127606.1 → NP_001121078.1  tubulin epsilon and delta complex protein 2

      See identical proteins and their annotated locations for NP_001121078.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166509
      UniProtKB/TrEMBL
      A6HCR0, B2GV34
      Related
      ENSRNOP00000046320.3, ENSRNOT00000047734.5
      Conserved Domains (1) summary
      pfam15764
      Location:151 → 432
      DUF4693; Domain of unknown function (DUF4693)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13750586..13755775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084981.2 → XP_038940909.1  tubulin epsilon and delta complex protein 2 isoform X1

      Conserved Domains (1) summary
      pfam15764
      Location:66 → 298
      DUF4693; Domain of unknown function (DUF4693)
    Nucleotide Protein Strain
    Heading Accession and Version

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