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    grem1b gremlin 1b [ Danio rerio (zebrafish) ]

    Gene ID: 100005728, updated on 27-Mar-2024

    Summary

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    Official Symbol
    grem1bprovided by ZNC
    Official Full Name
    gremlin 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-090218-21
    See related
    Ensembl:ENSDARG00000104618 AllianceGenome:ZFIN:ZDB-GENE-090218-21
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:eu2461; si:ch1073-209e23.2
    Summary
    Predicted to enable BMP binding activity and receptor ligand activity. Predicted to be involved in animal organ morphogenesis and sequestering of BMP from receptor via BMP binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in musculature system; myotome; pectoral fin; pharyngeal arch; and somite. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 17
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (80171..86762, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (81700..82440, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene formin-like Neighboring gene si:ch1073-209e23.1 Neighboring gene Rho GTPase activating protein 11A Neighboring gene actin alpha cardiac muscle 1b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Comparative Transcriptome Analysis of the Regenerating Zebrafish Telencephalon Unravels a Resource With Key Pathways During Two Early Stages and Activation of Wnt/β-Catenin Signaling at the Early Wound Healing Stage. Demirci Y, et al. Front Cell Dev Biol, 2020. PMID 33163496, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables receptor ligand activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sequestering of BMP from receptor via BMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gremlin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      80171..86762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021467246.1 → XP_021322921.1  gremlin-1

      UniProtKB/TrEMBL
      A0A8M9PKX9
      Related
      ENSDARP00000140230.1, ENSDART00000163657.2
      Conserved Domains (1) summary
      pfam03045
      Location:92 → 199
      DAN; DAN domain
    Nucleotide Protein Strain
    Heading Accession and Version

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