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    cacng8b calcium channel, voltage-dependent, gamma subunit 8b [ Danio rerio (zebrafish) ]

    Gene ID: 100003329, updated on 11-Apr-2024

    Summary

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    Official Symbol
    cacng8bprovided by ZNC
    Official Full Name
    calcium channel, voltage-dependent, gamma subunit 8bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-100921-72
    See related
    Ensembl:ENSDARG00000070626 AllianceGenome:ZFIN:ZDB-GENE-100921-72
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-117n22.1
    Summary
    Predicted to enable channel regulator activity and voltage-gated calcium channel activity. Predicted to be involved in several processes, including neurotransmitter receptor internalization; neurotransmitter receptor transport, postsynaptic endosome to lysosome; and postsynaptic neurotransmitter receptor diffusion trapping. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Orthologous to human CACNG8 (calcium voltage-gated channel auxiliary subunit gamma 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (12882275..12953856, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (12992186..13063752, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene U2 small nuclear RNA auxiliary factor 2a Neighboring gene calcium channel, voltage-dependent, gamma subunit 6b Neighboring gene calcium channel, voltage-dependent, gamma subunit 7b Neighboring gene protein kinase C, gamma

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of AMPA receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmission of nerve impulse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    voltage-dependent calcium channel gamma-4 subunit-like; voltage-dependent calcium channel gamma-8 subunit-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      12882275..12953856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001342886.7 → XP_001342922.4  voltage-dependent calcium channel gamma-4 subunit-like isoform X1

      See identical proteins and their annotated locations for XP_001342922.4

      UniProtKB/TrEMBL
      A0A8M9PMW7, E9QCW1
      Related
      ENSDARP00000094670.4, ENSDART00000103894.5
      Conserved Domains (1) summary
      cl21598
      Location:5 → 203
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    2. XM_021466865.1 → XP_021322540.1  voltage-dependent calcium channel gamma-4 subunit-like isoform X1

      UniProtKB/TrEMBL
      A0A8M9PMW7, E9QCW1
      Related
      ENSDARP00000155289.1, ENSDART00000184221.1
      Conserved Domains (1) summary
      cl21598
      Location:5 → 203
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    3. XM_009292141.3 → XP_009290416.1  voltage-dependent calcium channel gamma-8 subunit-like isoform X2

      UniProtKB/TrEMBL
      A0A8M3AIY9
      Conserved Domains (1) summary
      cl21598
      Location:1 → 83
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases