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    rab5A Rab GTPase [ Dictyostelium discoideum AX4 ]

    Gene ID: 8618246, updated on 11-Apr-2024

    Summary

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    Gene symbol
    rab5A
    Gene description
    Rab GTPase
    Primary source
    dictyBase:DDB_G0271984
    Locus tag
    DDB_G0271984
    Gene type
    protein coding
    RNA name
    Rab GTPase
    RefSeq status
    PROVISIONAL
    Organism
    Dictyostelium discoideum AX4 (strain: AX4)
    Lineage
    Eukaryota; Amoebozoa; Mycetozoa; Dictyosteliida; Dictyostelium
    Old locus tag
    DDBDRAFT_0168594; DDBDRAFT_0229401; DDB_0168594; DDB_0229401
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    3
    Sequence:
    Chromosome: 2; NC_007088.5 (1113320..1114208)

    Chromosome 2 - NC_007088.5Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Ras guanine nucleotide exchange factor Neighboring gene NOT2/NOT3/NOT5 family protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007088.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Live imaging of Mycobacterium marinum infection in Dictyostelium discoideum. Barisch C, et al. Methods Mol Biol, 2015. PMID 25779329
    2. The PripA-TbcrA complex-centered Rab GAP cascade facilitates macropinosome maturation in Dictyostelium. Tu H, et al. Nat Commun, 2022 Apr 4. PMID 35379834, Free PMC Article
    3. Functional analysis of novel Rab GTPases identified in the proteome of purified Legionella-containing vacuoles from macrophages. Hoffmann C, et al. Cell Microbiol, 2014 Jul. PMID 24373249
    4. Comparative Proteomics of Purified Pathogen Vacuoles Correlates Intracellular Replication of Legionella pneumophila with the Small GTPase Ras-related protein 1 (Rap1). Schmölders J, et al. Mol Cell Proteomics, 2017 Apr. PMID 28183814, Free PMC Article
    5. Dictyostelium lipid droplets host novel proteins. Du X, et al. Eukaryot Cell, 2013 Nov. PMID 24036346, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by dictyBase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of phagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in early phagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet HDA PubMed 
    located_in macropinosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pathogen-containing vacuole HDA PubMed 
    located_in pathogen-containing vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Names
    Rab GTPase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007088.5 Reference assembly

      Range
      1113320..1114208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_640265.1 → XP_645357.1  Rab GTPase [Dictyostelium discoideum AX4]

      See identical proteins and their annotated locations for XP_645357.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q55AA9, Q86JP3
      Conserved Domains (2) summary
      cd01860
      Location:9 → 171
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
      pfam00071
      Location:11 → 172
      Ras; Ras family
    Nucleotide Protein
    Heading Accession and Version

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