U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Elf1 E74 like ETS transcription factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85424, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Elf1provided by RGD
    Official Full Name
    E74 like ETS transcription factor 1provided by RGD
    Primary source
    RGD:620697
    See related
    Ensembl:ENSRNOG00000011762 AllianceGenome:RGD:620697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated. Predicted to be active in nucleus. Orthologous to human ELF1 (E74 like ETS transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 308.9), Spleen (RPKM 189.1) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Elf1 in Genome Data Viewer
    Location:
    15q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61354026..61395762)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (54890644..54986721)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (61772544..61868442)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481995 Neighboring gene WW domain binding protein 4 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 8 Neighboring gene microfibrillar-associated protein 1-like Neighboring gene SGT1 homolog, MIS12 kinetochore complex assembly cochaperone Neighboring gene uncharacterized LOC134481994 Neighboring gene chondromodulin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1. Nishiyama C, et al. Biosci Biotechnol Biochem, 2000 Dec. PMID 11210123
    2. Transcriptional regulation of CD1D1 by Ets family transcription factors. Geng Y, et al. J Immunol, 2005 Jul 15. PMID 16002702
    3. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1. Oettgen P, et al. Mol Cell Biol, 1996 Sep. PMID 8756667, Free PMC Article
    4. Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2. Carpino N, et al. Immunity, 2004 Jan. PMID 14738763
    5. Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells. Song H, et al. J Biol Chem, 2009 Oct 16. PMID 19674970, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ETS-related transcription factor Elf-1
    Names
    E74-like factor 1 (ets domain transcription factor)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053520.2 → NP_445972.2  ETS-related transcription factor Elf-1

      See identical proteins and their annotated locations for NP_445972.2

      Status: VALIDATED

      Source sequence(s)
      AB030215, AB030216, CB782606
      UniProtKB/TrEMBL
      A6HTZ6, G3V9V2, Q9EQY3
      Conserved Domains (3) summary
      smart00413
      Location:206 → 288
      ETS; erythroblast transformation specific domain
      PRK10811
      Location:351 → 531
      rne; ribonuclease E; Reviewed
      pfam12310
      Location:2 → 111
      Elf-1_N; Transcription factor protein N terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      61354026..61395762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093704.2 → XP_038949632.1  ETS-related transcription factor Elf-1 isoform X1

      UniProtKB/TrEMBL
      A6HTZ8, A6HTZ9, Q9EQY2, Q9EQY3
      Related
      ENSRNOP00000072421.1
      Conserved Domains (3) summary
      smart00413
      Location:170 → 252
      ETS; erythroblast transformation specific domain
      PRK10811
      Location:315 → 495
      rne; ribonuclease E; Reviewed
      pfam12310
      Location:2 → 69
      Elf-1_N; Transcription factor protein N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous