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    ADH1 alcohol dehydrogenase ADH1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854068, updated on 13-Apr-2024

    Summary

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    Gene symbol
    ADH1
    Gene description
    alcohol dehydrogenase ADH1
    Primary source
    SGD:S000005446
    Locus tag
    YOL086C
    See related
    AllianceGenome:SGD:S000005446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ADC1
    Summary
    Enables alcohol dehydrogenase (NAD+) activity; melatonin binding activity; and methylglyoxal reductase (NADH-dependent) activity. Involved in NADH oxidation; alcohol biosynthetic process; and regulation of viral genome replication. Located in cytoplasm and replication compartment. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (159548..160594, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Duf1p Neighboring gene Mhf1p Neighboring gene uncharacterized protein Neighboring gene Phm7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Thr45Gly substitution in yeast alcohol dehydrogenase substantially decreases catalysis, alters pH dependencies, and disrupts the proton relay system. Pal S, et al. Chem Biol Interact, 2021 Nov 1. PMID 34529977, Free PMC Article
    2. Substitution of cysteine-153 ligated to the catalytic zinc in yeast alcohol dehydrogenase with aspartic acid and analysis of mechanisms of related medium chain dehydrogenases. Kim K, et al. Chem Biol Interact, 2019 Apr 1. PMID 30721696
    3. Stability of proteins on hydrophilic surfaces. Grimaldi J, et al. Langmuir, 2015 Jan 27. PMID 25533285
    4. Screening of high-level 4-hydroxy-2 (or 5)-ethyl-5 (or 2)-methyl-3(2H)-furanone-producing strains from a collection of gene deletion mutants of Saccharomyces cerevisiae. Uehara K, et al. Appl Environ Microbiol, 2015 Jan. PMID 25362059, Free PMC Article
    5. Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants. Laadan B, et al. Microb Cell Fact, 2014 Aug 9. PMID 25287956, Free PMC Article

    See all (280) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Subunit B may represent an intermediate in the mechanism after coenzyme and alcohol bind and before the conformation changes to the closed form and the alcohol oxygen binds to the zinc and displaces Glu-67.
      Title: Mechanistic implications from structures of yeast alcohol dehydrogenase complexed with coenzyme and an alcohol.
    2. key role of Y295C mutation in HMF reduction by Adh1p.
      Title: Furaldehyde substrate specificity and kinetics of Saccharomyces cerevisiae alcohol dehydrogenase 1 variants.
    3. Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depot structures.
      Title: Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depots structures.
    4. mutation of the ADH1 gene improves lactate production in the yeast Saccharomyces cerevisiae
      Title: Double mutation of the PDC1 and ADH1 genes improves lactate production in the yeast Saccharomyces cerevisiae expressing the bovine lactate dehydrogenase gene.
    5. a sequence -YSGVCHTDLHAWHGDWPLPVK- in the polypeptide chain possesses chaperone-like activity
      Title: Mechanism of thermal aggregation of yeast alcohol dehydrogenase I: role of intramolecular chaperone.
    6. The identification and characterization of a mutated alcohol dehydrogenase 1 from the industrial Saccharomyces cerevisiae strain TMB3000 that mediates the NADH-dependent reduction of 5-hydroxymethylfurfural (HMF) to 2,5-bis-hydroxymethylfuran.
      Title: Identification of an NADH-dependent 5-hydroxymethylfurfural-reducing alcohol dehydrogenase in Saccharomyces cerevisiae.
    7. A yeast strain with an extra copy of the ADH1 gene (2xADH1) demonstrated increased survival in stationary phase and a 30% extension in replicative life span.
      Title: Chronological and replicative life-span extension in Saccharomyces cerevisiae by increased dosage of alcohol dehydrogenase 1.
    8. During zinc deficiency, Zap1 mediates the repression of two of the most abundant zinc-requiring enzymes.
      Title: Repression of ADH1 and ADH3 during zinc deficiency by Zap1-induced intergenic RNA transcripts.
    9. analysis of the oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro
      Title: The oxidation of yeast alcohol dehydrogenase-1 by hydrogen peroxide in vitro.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables allyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables butanol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables melatonin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylglyoxal reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylglyoxal reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables octanol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NADH oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NADH oxidation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid catabolic process to alcohol via Ehrlich pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycolytic fermentation to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    alcohol dehydrogenase ADH1
    NP_014555.1
    • Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      159548..160594 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183340.1 → NP_014555.1  TPA: alcohol dehydrogenase ADH1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014555.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1Y3, P00330
      UniProtKB/TrEMBL
      A0A8H4BVB5, S5S176
      Conserved Domains (1) summary
      cd08297
      Location:7 → 345
      CAD3; Cinnamyl alcohol dehydrogenases (CAD)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00330.5

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