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    Cox4i2 cytochrome c oxidase subunit 4I2 [ Mus musculus (house mouse) ]

    Gene ID: 84682, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cox4i2provided by MGI
    Official Full Name
    cytochrome c oxidase subunit 4I2provided by MGI
    Primary source
    MGI:MGI:2135755
    See related
    Ensembl:ENSMUSG00000009876 AllianceGenome:MGI:2135755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cox4b; CoxIV-2
    Summary
    Predicted to enable cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrial membrane. Is expressed in several structures, including alimentary system; cardiovascular system; hindlimb musculature; nervous system; and sensory organ. Orthologous to human COX4I2 (cytochrome c oxidase subunit 4I2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 10.6), limb E14.5 (RPKM 2.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 75.41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152596093..152606957)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152753916..152765039)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 1, HLH protein Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 32057 Neighboring gene STARR-seq mESC enhancer starr_06077 Neighboring gene BCL2-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152614671-152614780 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152615325-152615529 Neighboring gene STARR-seq mESC enhancer starr_06078 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152620177-152620625 Neighboring gene STARR-seq mESC enhancer starr_06080 Neighboring gene predicted gene, 32211 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152642094-152642203 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:152642211-152642412 Neighboring gene STARR-seq mESC enhancer starr_06082 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152651505-152651806 Neighboring gene STARR-positive B cell enhancer mm9_chr2:152656963-152657264 Neighboring gene STARR-positive B cell enhancer ABC_E514 Neighboring gene TPX2, microtubule-associated Neighboring gene microRNA 5622

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing. Sommer N, et al. Circ Res, 2017 Aug 4. PMID 28620066, Free PMC Article
    2. Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology. Hüttemann M, et al. FASEB J, 2012 Sep. PMID 22730437, Free PMC Article
    3. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex. Li Y, et al. J Bioenerg Biomembr, 2006 Dec. PMID 17091399, Free PMC Article
    4. Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons. Horvat S, et al. J Neurochem, 2006 Nov. PMID 16981895
    5. Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines. Horsch M, et al. PLoS One, 2015. PMID 26263558, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acute O2 sensing through HIF2alpha-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
      Title: Acute O(2) sensing through HIF2α-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors.
    2. Cox4i2 is essential for acute but not chronic pulmonary oxygen sensing by triggering mitochondrial hyperpolarization.
      Title: Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing.
    3. Data (including data from cells of transgenic mouse embryos) suggest Hif1a (hypoxia inducible factor 1 alpha subunit) up-regulates transcription of heart/muscle isoform Cox7a1 under hypoxia; hypoxic induction of isoform Cox4i2 is HIF1a-independent.
      Title: Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.
    4. propose a model in which reduced tissue ATP levels explain protection from airway hyperresponsiveness, i.e., absence of COX4i2 leads to reduced lung COX activity and ATP levels, which results in impaired airway constriction
      Title: Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.
    5. the presence of the COX isoform IV-2 suppresses the sensitivity of COX to its allosteric regulator ATP and overrules the regulation of COX by the cellular energy level
      Title: Effect of hypoxia on the transcription pattern of subunit isoforms and the kinetics of cytochrome c oxidase in cortical astrocytes and cerebellar neurons.
    6. Under conditions of reduced oxygen availability, hypoxia-inducible factor 1 reciprocally regulates COX4 subunit expression by activating transcription of the genes encoding COX4-2 and LON, a mitochondrial protease that is required for COX4-1 degradation.
      Title: HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.
    7. Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex.
      Title: Cytochrome c oxidase subunit IV is essential for assembly and respiratory function of the enzyme complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables cytochrome-c oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex IV ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 4 isoform 2, mitochondrial
    Names
    cytochrome c oxidase, subunit IVb
    NP_444321.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053091.2 → NP_444321.1  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_444321.1

      Status: VALIDATED

      Source sequence(s)
      AL731857
      Consensus CDS
      CCDS16898.1
      UniProtKB/Swiss-Prot
      Q91W29
      Related
      ENSMUSP00000010020.6, ENSMUST00000010020.12
      Conserved Domains (1) summary
      pfam02936
      Location:38 → 171
      COX4; Cytochrome c oxidase subunit IV

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      152596093..152606957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91W29.1 GenPept UniProtKB/Swiss-Prot:Q91W29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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