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    WNK1 with no lysine (K) kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819651, updated on 15-Feb-2024

    Summary

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    Gene symbol
    WNK1
    Gene description
    with no lysine (K) kinase 1
    Primary source
    Araport:AT3G04910
    Locus tag
    AT3G04910
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATWNK1; T9J14.14; T9J14_14; with no lysine (K) kinase 1; ZIK4
    Summary
    Serine/threonine protein kinase, whose transcription is regulated by circadian rhythm.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (1354536..1358235)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene adenine phosphoribosyltransferase-like protein, putative (DUF2358) Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Defensin-like (DEFL) family protein Neighboring gene Ribosomal protein S24e family protein Neighboring gene DNA-binding storekeeper protein-related transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The APRR3 component of the clock-associated APRR1/TOC1 quintet is phosphorylated by a novel protein kinase belonging to the WNK family, the gene for which is also transcribed rhythmically in Arabidopsis thaliana. Murakami-Kojima M, et al. Plant Cell Physiol, 2002 Jun. PMID 12091722
    2. Compilation and characterization of a novel WNK family of protein kinases in Arabiodpsis thaliana with reference to circadian rhythms. Nakamichi N, et al. Biosci Biotechnol Biochem, 2002 Nov. PMID 12506983
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001035560.1
    NM_001125104.1
    NM_111363.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    with no lysine (K) kinase 1
    NP_001030637.1
    • with no lysine (K) kinase 1 (WNK1); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation, circadian rhythm; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT5G28080.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001118576.1
    • with no lysine (K) kinase 1 (WNK1); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation, circadian rhythm; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT5G28080.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_187142.1
    • with no lysine (K) kinase 1 (WNK1); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation, circadian rhythm; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Protein kinase superfamily protein (TAIR:AT5G28080.2); Has 101031 Blast hits to 100159 proteins in 3121 species: Archae - 77; Bacteria - 9426; Metazoa - 36599; Fungi - 9721; Plants - 28152; Viruses - 368; Other Eukaryotes - 16688 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1354536..1358235
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111363.4 → NP_187142.1  with no lysine (K) kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187142.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9CAV6
      UniProtKB/TrEMBL
      A0A178VA73, A0A5S9X9T5, A0A654F9F9
      Conserved Domains (2) summary
      cd13983
      Location:22 → 281
      STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
      pfam12202
      Location:405 → 455
      OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

    2. NM_001035560.1 → NP_001030637.1  with no lysine (K) kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030637.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VA73, A0A5S9X9T5, F4J622
      Conserved Domains (2) summary
      smart00220
      Location:16 → 258
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13983
      Location:16 → 258
      STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase

    3. NM_001125104.1 → NP_001118576.1  with no lysine (K) kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118576.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VA73, A0A5S9X9T5, B3H6U2
      Conserved Domains (2) summary
      smart00220
      Location:2 → 155
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:2 → 155
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAV6.1

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