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    rab6a RAB6A, member RAS oncogene family [ Danio rerio (zebrafish) ]

    Gene ID: 793785, updated on 27-Mar-2024

    Summary

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    Official Symbol
    rab6aprovided by ZNC
    Official Full Name
    RAB6A, member RAS oncogene familyprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2849
    See related
    Ensembl:ENSDARG00000103714 AllianceGenome:ZFIN:ZDB-GENE-040426-2849
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb43c01; zgc:55788; wu:fb43c01
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See rab6a in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (36695597..36711701)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (36751839..36767943)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B13 Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene aurora kinase-like Neighboring gene pleckstrin homology domain containing B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization. Fogerty J, et al. Adv Exp Med Biol, 2016. PMID 26427413, Free PMC Article
    2. In vivo imaging of molecular interactions at damaged sarcolemma. Roostalu U, et al. Dev Cell, 2012 Mar 13. PMID 22421042
    3. Rab33a and Rab33ba mediate the outgrowth of forebrain commissural axons in the zebrafish brain. Huang L, et al. Sci Rep, 2019 Feb 12. PMID 30755680, Free PMC Article
    4. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
    5. A plasmid library of full-length zebrafish rab proteins for in vivo cell biology. Hall TE, et al. Cell Logist, 2017. PMID 28396820, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that basal body docking was unaffected in dynein 1 (dync1h1) mutation, but rab GTP-binding protein Rab6 expression was reduced.
      Title: Mutations in the Dynein1 Complex are Permissible for Basal Body Migration in Photoreceptors but Alter Rab6 Localization.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC55788

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-6A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328529.1 → NP_001315458.1  ras-related protein Rab-6A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1). Variants 1 and 2 encode isoforms (1 and 2, respectively) of the same length that differ in their amino acid sequence.
      Source sequence(s)
      AL845435, CU694807
      UniProtKB/TrEMBL
      A0A8M3BD98, A9ULS4
      Related
      ENSDARP00000130990.1, ENSDART00000169015.2
      Conserved Domains (2) summary
      smart00175
      Location:14 → 171
      RAB; Rab subfamily of small GTPases
      cd01861
      Location:14 → 174
      Rab6; Rab GTPase family 6 (Rab6)

    2. NM_001328530.1 → NP_001315459.1  ras-related protein Rab-6A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. Variants 1 and 2 encode isoforms (1 and 2, respectively) of the same length that differ in their amino acid sequence.
      Source sequence(s)
      AL845435, CU694807, EH453941
      UniProtKB/TrEMBL
      A0A0R4IH39, A0A8M1P3Z5
      Related
      ENSDARP00000134740.1, ENSDART00000171392.2
      Conserved Domains (2) summary
      smart00175
      Location:14 → 171
      RAB; Rab subfamily of small GTPases
      cd01861
      Location:14 → 174
      Rab6; Rab GTPase family 6 (Rab6)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      36695597..36711701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305567.2 → XP_009303842.1  ras-related protein Rab-6A isoform X2

      UniProtKB/TrEMBL
      A0A0R4IH39, A0A8M1P3Z5
      Conserved Domains (2) summary
      smart00175
      Location:14 → 171
      RAB; Rab subfamily of small GTPases
      cd01861
      Location:14 → 174
      Rab6; Rab GTPase family 6 (Rab6)

    2. XM_009305566.1 → XP_009303841.1  ras-related protein Rab-6A isoform X1

      See identical proteins and their annotated locations for XP_009303841.1

      UniProtKB/TrEMBL
      A0A8M3BD98, A9ULS4
      Conserved Domains (2) summary
      smart00175
      Location:14 → 171
      RAB; Rab subfamily of small GTPases
      cd01861
      Location:14 → 174
      Rab6; Rab GTPase family 6 (Rab6)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_214765.1: Suppressed sequence

      Description
      NM_214765.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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