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    ZNF155 zinc finger protein 155 [ Homo sapiens (human) ]

    Gene ID: 7711, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF155provided by HGNC
    Official Full Name
    zinc finger protein 155provided by HGNC
    Primary source
    HGNC:HGNC:12940
    See related
    Ensembl:ENSG00000204920 MIM:604086; AllianceGenome:HGNC:12940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    pHZ-96
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 3.4), adrenal (RPKM 2.6) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF155 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43984188..43998326)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46807096..46821233)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44488340..44502478)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF45 antisense RNA 1 Neighboring gene zinc finger protein 45 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14747 Neighboring gene zinc finger protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10732 Neighboring gene ZNF230 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14748 Neighboring gene zinc finger protein 230 Neighboring gene ZNF222 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis of a conserved zinc finger gene cluster on human chromosome 19q and mouse chromosome 7. Shannon M, et al. Genomics, 1996 Apr 1. PMID 8617494
    2. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Tommerup N, et al. Genomics, 1995 May 20. PMID 7557990
    3. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
    4. Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. Tu LC, et al. Mol Cell Proteomics, 2007 Apr. PMID 17220478
    5. The DNA sequence and biology of human chromosome 19. Grimwood J, et al. Nature, 2004 Apr 1. PMID 15057824

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC161655

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 155
    Names
    KRAB A domain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260486.2 → NP_001247415.2  zinc finger protein 155 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC006213
      Consensus CDS
      CCDS12634.1
      UniProtKB/Swiss-Prot
      A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
      Related
      ENSP00000481677.1, ENST00000611002.4
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:202 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001260487.2 → NP_001247416.2  zinc finger protein 155 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC006213
      Consensus CDS
      CCDS12634.1
      UniProtKB/Swiss-Prot
      A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:202 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001260488.2 → NP_001247417.2  zinc finger protein 155 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to variant 1.
      Source sequence(s)
      AC006213
      Consensus CDS
      CCDS58668.1
      Related
      ENSP00000385163.2, ENST00000407951.6
      Conserved Domains (3) summary
      smart00349
      Location:19 → 78
      KRAB; krueppel associated box
      COG5048
      Location:213 → 497
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_003445.4 → NP_003436.4  zinc finger protein 155 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 3 and 4 encode the same isoform.
      Source sequence(s)
      AC006213
      Consensus CDS
      CCDS12634.1
      UniProtKB/Swiss-Prot
      A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
      Related
      ENSP00000465691.1, ENST00000590615.5
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:202 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_198089.3 → NP_932355.3  zinc finger protein 155 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC006213
      Consensus CDS
      CCDS12634.1
      UniProtKB/Swiss-Prot
      A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14
      Related
      ENSP00000270014.1, ENST00000270014.7
      Conserved Domains (3) summary
      smart00349
      Location:8 → 67
      KRAB; krueppel associated box
      COG5048
      Location:202 → 486
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:206 → 226
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43984188..43998326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439370.1 → XP_047295326.1  zinc finger protein 155 isoform X1

    2. XM_024451694.2 → XP_024307462.1  zinc finger protein 155 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:19 → 78
      KRAB; krueppel associated box
      COG5048
      Location:213 → 497
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_047439372.1 → XP_047295328.1  zinc finger protein 155 isoform X1

    4. XM_011527278.4 → XP_011525580.1  zinc finger protein 155 isoform X1

      See identical proteins and their annotated locations for XP_011525580.1

      UniProtKB/Swiss-Prot
      Q12901
      Conserved Domains (3) summary
      smart00349
      Location:19 → 78
      KRAB; krueppel associated box
      COG5048
      Location:213 → 497
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:217 → 237
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_047439373.1 → XP_047295329.1  zinc finger protein 155 isoform X1

    6. XM_047439371.1 → XP_047295327.1  zinc finger protein 155 isoform X2

      UniProtKB/Swiss-Prot
      A2BDE6, B2RB63, B4DM95, J3KQ08, Q12901, Q6AZZ8, Q9UIE1, Q9UK14

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46807096..46821233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322019.1 → XP_054177994.1  zinc finger protein 155 isoform X1

    2. XM_054322022.1 → XP_054177997.1  zinc finger protein 155 isoform X1

    3. XM_054322021.1 → XP_054177996.1  zinc finger protein 155 isoform X1

    4. XM_054322018.1 → XP_054177993.1  zinc finger protein 155 isoform X1

    5. XM_054322023.1 → XP_054177998.1  zinc finger protein 155 isoform X1

    6. XM_054322020.1 → XP_054177995.1  zinc finger protein 155 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12901.4 GenPept UniProtKB/Swiss-Prot:Q12901

    Gene LinkOut

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