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    MSRB1 methionine sulfoxide reductase B1 [ Macaca mulatta (Rhesus monkey) ]

    Gene ID: 693358, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MSRB1provided by VGNC
    Official Full Name
    methionine sulfoxide reductase B1provided by VGNC
    Primary source
    VGNC:VGNC:99524
    See related
    Ensembl:ENSMMUG00000007936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Macaca mulatta
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
    Also known as
    SEPX1
    Summary
    The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 20
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    103 current Mmul_10 (GCF_003339765.1) 20 NC_041773.1 (1964370..1970332, complement)
    102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 20 NC_027912.1 (1923800..1929473, complement)

    Chromosome 20 - NC_041773.1Genomic Context describing neighboring genes Neighboring gene meiosis specific with OB-fold Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 6 Neighboring gene ribosomal protein L3 like Neighboring gene NADH:ubiquinone oxidoreductase subunit B10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new rhesus macaque assembly and annotation for next-generation sequencing analyses. Zimin AV, et al. Biol Direct, 2014 Oct 14. PMID 25319552, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables peptide-methionine (R)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    methionine-R-sulfoxide reductase B1
    Names
    selenoprotein X, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346686.2 → NP_001333615.2  methionine-R-sulfoxide reductase B1

      Status: REVIEWED

      Source sequence(s)
      QNVO02000290
      UniProtKB/TrEMBL
      A0A1D5Q8E9, F7HSX6
      Related
      ENSMMUP00000010414.4, ENSMMUT00000011106.4
      Conserved Domains (1) summary
      PRK05550
      Location:7 → 114
      PRK05550; bifunctional methionine sulfoxide reductase B/A protein; Provisional

    RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmul_10 Primary Assembly

    Genomic

    1. NC_041773.1 Reference Mmul_10 Primary Assembly

      Range
      1964370..1970332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001114750.2: Suppressed sequence

      Description
      NM_001114750.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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