Bmp8b bone morphogenetic protein 8b [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bmp8bprovided by RGD
Official Full Name: bone morphogenetic protein 8bprovided by RGD
Primary source: RGD:1591873
See related: Ensembl:ENSRNOG00000033209 AllianceGenome:RGD:1591873
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable BMP receptor binding activity and cytokine activity. Predicted to be involved in BMP signaling pathway; SMAD protein signal transduction; and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to be active in extracellular space. Orthologous to human BMP8A (bone morphogenetic protein 8a) and BMP8B (bone morphogenetic protein 8b). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 5.6), Lung (RPKM 4.3) and 9 other tissues See more
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Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140671117..140696450)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135386058..135411337)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (140803387..140821104)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome.
Title: Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome.
Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.
Title: Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.
A functional link between AMPK and orexin mediates the effect of BMP8B on energy balance.
Title: A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.

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Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in diet induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in germ cell development	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

Preferred Names: bone morphogenetic protein 8B; uncharacterized protein Bmp8b

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