Herpud1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Herpud1provided by MGI
Official Full Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1provided by MGI
Primary source: MGI:MGI:1927406
See related: Ensembl:ENSMUSG00000031770 AllianceGenome:MGI:1927406
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SUP; Herp; Mifl
Summary: Enables ubiquitin ligase-substrate adaptor activity. Involved in protein targeting to ER; regulation of ER-associated ubiquitin-dependent protein catabolic process; and regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within endoplasmic reticulum unfolded protein response; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum quality control compartment. Is integral component of membrane. Is expressed in several structures, including clavicle; craniocervical region bone; early conceptus; and olfactory epithelium. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 149.4), kidney adult (RPKM 146.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C5; 8 46.46 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (95113057..95121999)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (94386429..94395371)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification.
Title: Herpud1 deficiency alleviates homocysteine-induced aortic valve calcification.
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Title: The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Herp knockout protects against nonalcoholic fatty liver disease in mice on a high fat diet.
Title: Herp knockout protects against nonalcoholic fatty liver disease in mice on a high fat diet.
Circ_002664/miR-182-5p/Herpud1 pathway importantly contributes to OGD/R-induced neuronal cell apoptosis.
Title: Circ_002664/miR-182-5p/Herpud1 pathway importantly contributes to OGD/R-induced neuronal cell apoptosis.
Herpud1 deficiency could reduce amyloid-beta40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway.
Title: Herpud1 deficiency could reduce amyloid-β40 expression and thereby suppress homocysteine-induced atherosclerosis by blocking the JNK/AP1 pathway.
the absence of Herpud1 generates a pathological hypertrophic phenotype by regulating IP3R protein levels. Herpud1 is a novel negative regulator of pathological cardiac hypertrophy.
Title: Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation.
ER protein with ubiquitin like domain 1(Herpud1) was upregulated in IL-4-treated M2 macrophage cells.
Title: ER-localized protein-Herpud1 is a new mediator of IL-4-induced macrophage polarization and migration.
that ERAD and proteasomal degradation were activated and that HERPUD1 expression was increased as osteoblast differentiation progressed
Title: A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization.
Herp deficiency inhibits the phenotypic switch of vascular smooth muscle cells and the development of atherosclerosis.
Title: Knockdown of Herp alleviates hyperhomocysteinemia mediated atherosclerosis through the inhibition of vascular smooth muscle cell phenotype switching.
HERP depletion inhibits zearalenone-induced apoptosis of ovarian granulosa cells through autophagy activation and apoptotic pathway inhibition.
Title: HERP depletion inhibits zearalenone-induced apoptosis through autophagy activation in mouse ovarian granulosa cells.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Herpud1 (e-PCR), detects polymorphism
- UniSTS:532488

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endoplasmic reticulum unfolded protein response	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to ER	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of ERAD pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to endoplasmic reticulum stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Lewy body core	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum quality control compartment	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357205.1 → NP_001344134.1 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 2

Status: VALIDATED

Source sequence(s)

AK081688, AV229138, BY318096

Consensus CDS

CCDS90439.1

UniProtKB/TrEMBL

Q8C4N0, Q91WR9

Related

ENSMUSP00000034220.8, ENSMUST00000034220.8

Conserved Domains (1) summary

cd01790
Location:9 → 86

Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein
NM_022331.2 → NP_071726.1 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein isoform 1

See identical proteins and their annotated locations for NP_071726.1

Status: VALIDATED

Source sequence(s)

AB034991, AV229138, BY318096

Consensus CDS

CCDS22541.1

UniProtKB/Swiss-Prot

Q9JJK5

UniProtKB/TrEMBL

Q3TMN9, Q91WR9

Related

ENSMUSP00000124201.2, ENSMUST00000161576.8

Conserved Domains (2) summary

cd01790
Location:9 → 87

Herp_N; Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain protein

smart00213
Location:10 → 86

UBQ; Ubiquitin homologues