Official Symbol: SELEprovided by HGNC
Official Full Name: selectin Eprovided by HGNC
Primary Source: HGNC:10718
Locus Tag: RP1-117P20.2
See related: Ensembl:ENSG00000007908; HPRD:00566; MIM:131210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ELAM; ESEL; CD62E; ELAM1; LECAM2; SELE
Summary: The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq]

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GeneRIFs: Gene References Into Function What's a GeneRIF?

	1.	There was a significant correlation between E-selectin and ICAM1 in all patients.
	2.	The carbon monoxide releasing molecule (CORM-3) inhibits expression of vascular cell adhesion molecule-1 and E-selectin independently of haem oxygenase-1 expression.
	3.	Plasma levels are increased after induction of endotoxemia with E.coli LPS
	4.	E-selectin S128R and L554F polymorphisms are associated with susceptibility to ischemic stroke.
	5.	There was significant difference in the Ser128Arg polymorphism of E-selectin between periodontal patients and controls. There was an association between the presence of the 128Arg allele and periodontitis.
	6.	Plasma E-selectin and soluble ICAM1 levels were significantly higher in the TT or TC genotype compared to that of the CC genotype.
	7.	Expression of selectins (E and L) was detected mainly in the skin leukocytes in all biopsy samples of dermatitis herpetiformis and bullous pemphigoid.
	8.	Despite the fact that selectins play a role in the pathogenesis of MS and their encoding genes are located in regions associated with the disease, the selectin gene cluster studied likely does not influence the susceptibility to MS in Caucasians.
	9.	The S128R polymorphism is a constitutional factor associated with a higher risk of relapse and death in patients treated for colorectal cancer.
	10.	Data show that clinical outcomes of inoperable breast cancer were predicted by changes in VCAM-1 and E-selectin.
	11.	The levels of E-selectin, ICAM-1, IL-11, IRF-1, IL-6, IL-1beta and LIF genes expression in the B. pseudomallei-infected cells were 1.5-5 times lower than in the B. thailandensis-infected cells.
	12.	Transient expression of galectin-9L decreased E-selectin levels, while transient expression of galectin-9M or galectin-9S increased E-selectin levels in LoVo cells.
	13.	The cag pathogenicity island was found to be an important determinant for the upregulation of human endothelial E-selectin expression in vitro, and this process is probably dependent on the CagL protein, mediating binding to alpha5beta1 integrins.
	14.	Serum and intraocular concentrations of ICAM-1, VCAM-1, E-selectin, vWF were considerably higher in the subjects with proliferative diabetic retinopathy than in the controls.
	15.	data suggest that the A561C polymorphism of the E-selectin gene may be associated with disease progression in patients with chronic HBV infection
	16.	Podocalyxin-like protein is an E-/L-selectin ligand on colon carcinoma cells: comparative biochemical properties of selectin ligands in host and tumor cells.
	17.	serum E-selectin correlated with severity of joint disease in rheumatoid arthritis patients
	18.	Neither amniotic fluic ELAM-1 (endothelial leukocyte adhesion molecule 1) nor VCAM-1 (vascular cell adhesion molecule 1)levels correlated with cervical dilatation or with the duration of labor
	19.	Changes in nailfold capillaroscopy, endothelial cell activation markers (VEGF, endothelin-1, E-selectin, and thrombomodulin) and features of systemic lupus erythematosus suggest microvascular abnormalities in the clinical manifestation of the disease.
	20.	HuGE review of gene-disease association and gene-environment interaction. (HuGE Navigator)
	21.	Meta-analysis of gene-disease association. (HuGE Navigator)
	22.	In recently diagnosed hypertensive subjects, hsCRP and sE-selectin levels are related to awake systolic blood pressure variability.
	23.	OPG but not OPN stimulated a dose-dependent increase in the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and E-selectin by endothelial cells in the presence of TNF-alpha
	24.	Study points to synergistic interactions between 561A > C or 98G > T polymorphisms of E-selectin gene and hypercholesterolemia that cause a significant increase in the susceptibility to coronary artery disease.
	25.	NF-kappaB, but not p38, is critical for TNF-alpha-induced expression of ICAM-1, VCAM-1 and E-selectin
	26.	Angiostatin K1-3 induced E-selectin expression via AP1 and Ets-1 binding to the proximal E-selectin promoter (-356/+1), which was positively mediated by JNK activation.
	27.	Gb3 induces oxidative stress and up-regulates the expression of ICAM1, VACAM1 and selectin E in Fabry disease vascular endothelial cells.
	28.	Elevated serum sE-selectin was associated with a poor outcome of biliary atresia and probably plays a role in the physiopathology of liver injury in postoperative biliary atresia.
	29.	Report maspin, E-selectin, and P-selectin expressions in papillary thyroid carcinomas and their correlation with prognostic parameters.
	30.	Patients with inactive TA have elevated levels of sE-selectin, sVCAM-1, and sICAM-1 that might indicate persistent vasculopathy in clinically inactive disease.
	31.	VEGF, sVCAM-1, sICAM-1 and sE-selectin median levels were higher in hemodialysis patients compared to controls.
	32.	Levels of E-selectin positively correlated with high triglyceride levels in type 2 diabetic subjects with silent ischemia.
	33.	Higher serum concentrations of endothelin-1 (ET-1), E-selectin, and Thrombomodulin were observed in SLE patients in comparison with controls
	34.	Data suggest that squamous cell carcinomas evade the immune response at least in part by down-regulating vascular E-selectin and recruiting regulatory T cells.
	35.	correlations found between sVCAM-1, sICAM-1 and sELAM-1 and the presence of retinopathy suggest that cellular adhesion and neovascularization may be linked processes
	36.	Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
	37.	Oxidized LDL impairs angiogenic properties of endothelial progenitor cells at sub-apoptotic levels by downregulation of E-selectin and integrin alphavbeta5, both substantial mediators of EPC-endothelial cell interaction.
	38.	Suggest that E-selectin levels could be useful in the early assessment of the severity of acute pancreatitis.
	39.	Endothelial dysfunction exists in atrial fibrillation and is related to dysfuncion of E selectin levels.
	40.	Acetylcholine-induced vasodilation in the forearm, but not flow mediated vasodilation, was inversely related to CRP and e-selectin levels independently of traditional risk factors in elderly subjects
	41.	E-selectin regulates diapedesis of circulating cancer cells.
	42.	In women with subsequent preeclampsia, sL-selectin and sVCAM-1 concentrations were significantly lower, whereas sE-selectin, sP-selectin and sICAM-1 levels were significantly higher, compared with controls at mid-pregnancy (p<0.05).
	43.	Data show that in bullous pemphigoid, expression of E selectins was detected mainly in basal keratinocytes and in inflammatory infiltrates in the dermis.
	44.	CEA and CD44v cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin at elevated shear stresses.
	45.	A significant association of E-selectin and susceptibility to Graves' disease is found in a Chinese population.
	46.	E-selectin clusters in both clathrin-coated pits and lipid rafts of endothelial cells but is internalized in clathrin-coated pits.
	47.	Data show that P-selectin, but not L- or E-selectin, concentrations are significantly increased in male and female pseudoxanthoma elasticum patients.
	48.	Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
	49.	Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
	50.	Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
	51.	Observational study of gene-disease association. (HuGE Navigator)
	52.	Observational study of genotype prevalence. (HuGE Navigator)
	53.	Xenon, isoflurane, nitrous oxide, and morphine do not prevent TNF-alpha induced E-selectin expression.
	54.	soluble E-selectin and soluble P-selectin in blood plasma of labouring women do not appear to have a role in preeclampsia
	55.	Mean sICAM-1 value was higher in patients with active giant cell arteritis than in cluster headache patients during the active cluster period.
	56.	data are in keeping with the hypothesis that in systemic inflammation altered E-selectin shedding may play a role in arterial damage & implicates this adhesion molecule in atherosclerotic complications in a high-risk condition like end-stage renal disease
	57.	This is the first report of a leptospiral protein capable of up-regulating the expression of endothelial cell adhesion molecules ICAM-1 and E-selectin.
	58.	Increased blood levels in rheumatoid arthritis are diminished after treatment with methotrexate.
	59.	E-selectin Serl28Arg polymorphism is not associated with the risk of severe preeclampsia.
	60.	study demonstrates that the functional counter-receptors for E-selectin at the cell surface of Colo201 human colon cancer cells are localized in detergent-insoluble membrane microdomains (DIM).
	61.	E-selectin immunoadhesin decreases leukocyte attachment and rolling in vitro.
	62.	Eosinophil interaction with endothelial P-selectin is far more important than interaction with E-selectin for recruitment into the inflamed skin of patients with atopic dermatitis.
	63.	E-selectin is required for the antiangiogenic activity of endostatin in vivo and ex vivo and confers endostatin sensitivity to nonresponsive human endothelial cells in vitro
	64.	Cell expression in response to tobacco smoke extract.
	65.	E-selectin may play an important inflammation-related role in plaque development.
	66.	circulating soluble selectin E in acute myeloid leukemia is correlated with peripheral blast cell counts, extramedullaary infiltration, relapse and mortality
	67.	The adhesion of E-selectin expressing CHO cells to the coated mucins was analyzed in a flow system revealing that the MUC1 mucin adhered better than the CD43 mucin
	68.	the orientation and length of P-selectin, E-selectin, or CD16A receptor influences its rate of encountering and binding a surface ligand but does not subsequently affect the stability of binding
	69.	Hepatocyte growth factor ameliorates acute renal inflammation in part by downregulating E-selectin mediated macrophage adhesion to the inflamed endothelium.
	70.	Tibolone causes a rapid and sustained decrease in circulating levels of VCAMs; the effect is lost soon after stopping the treatment.
	71.	IVIG inhibits NF-kappaB activation induced by TNF-alpha in cultured endothelial cells of coronary arteries, thereby possibly modulating IL-6 production and E-selectin expression
	72.	enhanced expression of E-selectin may contribute to the development of diabetic maculopathy in type 2 diabetes
	73.	Endothelial cells have increased expression of VCAM-1, E-selectin, and ICAM-1 when exposed to sickle blood cells.
	74.	inhibition of cytokine induction of promoter by 17beta-estradiol
	75.	two SNPs in the E-selectin gene and six SNPs in the L-selectin gene were significantly associated with IgAN in Japanese patients
	76.	is a potent mediator of human dermal microvascular endothelial cell (HMVEC) chemotaxis, which is predominantly mediated through the Src and the phosphatidylinositiol 3-kinase (PI3K) pathways
	77.	The severity and diversity of the histopathology of lupus nephritis are partially associated with the expression of E-selectin, P-selectin, and VCAM-1 in glomeruli.
	78.	SR genotype of the E-selectin gene polymorphism in codon 128 is a genetic factor that may determine an individual's susceptibility for CAD in Chinese.
	79.	Localization of E-selectin in lipid rafts is necessary for its association with, and activation of, phospholipase C gamma.
	80.	The C allele at the +561 position of the E-selectin gene is associated with significantly reduced risk of developing sarcoidosis in patients with erythema nodosum.
	81.	sE-selectin may have a role in progression and metastasis of colorectal neoplasms
	82.	E-selectin and its ligand-sLeX are closely correlated with the metastasis of hepatocellular carcinoma
	83.	The E-selectin Ser128Arg polymorphism can functionally alter leukocyte-endothelial interactions as well as biochemical and biological consequences, which may account for the pathogenesis of myocardial infarction.
	84.	CD43 is a T-cell E-selectin ligand distinct from PSGL-1 which expands the role of CD43 in the regulation of T-cell trafficking.
	85.	Expresson is reduced in treatment with methotrexate in bullous pemphigoid.
	86.	Conjunctival biopsies excised from patients following cataract surgery did not show that endothelial E-selectin might play a role in the surgery-induced up-regulation of leukocyte rolling.
	87.	E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular adhesion molecule-1 (VCAM-1) were measured in serum from hypertensive patients with LV hypertrophy
	88.	A serine to arginine (S128R) polymorphism in E-selectin extends the range of lymphocytes recruited by E-selectin, which may provide a mechanistic link between this polymorphism and vascular inflammatory disease.
	89.	Our study suggests that the E-selectin polymorphism may be associated with severity of atherosclerotic disease, but does not allow us to conclude that it is actually a risk factor for atherosclerosis.
	90.	role of E-selectin in activating integrins to modulate adhesion and regulate integrin-mediated events
	91.	ICAM-1, VCAM-1, E-selectin and interleukin-6 expression are enhanced by glucose and regulated by poly(ADP-ribose) polymerase in human umbilical endothelial cells
	92.	Enhanced expression of E-selectin on the vascular endothelium of peripheral nerve in critically ill patients with neuromuscular disorders.
	93.	interacts with fuco-oligosaccharides of the blood group family
	94.	X-irradiation 2-5 h before stimulation decreased the characteristic transient expression of E-selectin after TNFalpha stimulation.
	95.	E-selectin has a role in promoting growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1
	96.	CD62L on human cultured T lymphoblasts is one of several glycoproteins that interacts directly with E-selectin and contributes to rolling under flow.
	97.	These findings suggest that the E-selectin S128R polymorphism can functionally affect tumor-endothelial interactions as well as motility and signaling properties of neoplastic cells that may modulate the metastatic phenotype.
	98.	Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1, E-selectin for adhesive interactions with human vascular endothelium under flow conditions
	99.	Downregulation of e-selectin is associated with nodal metastasis in breast cancer
	100.	G-CSF has a role in the induction of E-selectin ligands on myeloid cells, thus providing mechanistic insight into the pathobiology of G-CSF complications
	101.	Extravasated and oxidized LDL in xanthoma adds to foam cell recruitment by activating tyrosine kinase and inducing adhesion of monocytes to dermal microvascular endothelial cells through VCAM-1 and E-selectin.
	102.	Increases in serum E-selectin is associated with rheumatoid arthritis
	103.	circadian variations in healthy adults and in subjects with type II diabetes; possible role in increased vascular wall uptake of lipoproteins in diabetic subjects
	104.	role of phosphoserine-type di-leucine motif in E-selectin internalization
	105.	significant increase in plasma levels between day 1 and day 5 of G-CSF-induced stem cell mobilization; possible effect on leukocyte-endothelial cell interactions
	106.	Adrenomedullin and ACTH induce cell surface expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 on human umbilical vein endothelial cells.
	107.	minor trauma to skin may induce expression of E-selectin, ICAM-1 and IL-8
	108.	E-selectin is unique among selectins in its capacity for clustering sialylated ligands and transducing signals leading to neutrophil arrest in shear flow.
	109.	CLA and E-selectin are bound by T cells and have roles in skin inflammation
	110.	concluded that in conjunction with serum triglycerides and serum leptin, serum E-selectin is another important independent factor associated with insulin resistance in nonobese Japanese type 2 diabetic patients
	111.	Premature labor is associated with up-regulation of adhesion molecules in the lower uterine segment
	112.	central obese subjects with concomitant higher levels of selectin E and ACE DD genotype may be characterized by early cardiovascular alterations and then considered a particular subset of subjects at higher risk of cardiovascular disease
	113.	even a short-term exposure of endothelial cells (ECs) to high glucose concentration leads to their activation associated with increased expression of adhesion molecules such as ELAM-1, VCAM-1 and ICAM-1.
	114.	conclude that the E-selectin variants examined are not important genetic risk factors for type 2 diabetes in women
	115.	FBI-1 enhances transcription of the NF-kappaB-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB
	116.	Serum E-selectin, ICAM-1 and integrin beta1 expression levels are probably related to the metastasis and relapse of gastric cancer.
	117.	The sE-selectin, rheumatoid factor, and erythrocyte sedimentation rate, in addition to clinical indices, were associated with clinical activity in rheumatoid arthritis.
	118.	The periprocedural evaluation of sP-selectin and sE-selectin in peripheral venous blood in patients undergoing elective coronary stenting provides no prognostic information in terms of clinical restenosis prediction.
	119.	These results suggest that the Arg/Arg genotype of the E-selectin gene polymorphism in codon 128 is a genetic factor that may determine an individual's susceptibility for brucella infection.
	120.	These results suggest a BMI-specific effect of L/F554 polymorphism of the E-selectin gene on blood pressure, and strengthen the hypothesis that E-selectin is implicated in hypertension.
	121.	Data indicate that weight loss is more important than glycaemic control in regulating circulating levels of E-selectin in morbidly obese subjects.
	122.	Direct implication of adhesion molecules in the pathogenesis or progression of type 2 diabetic retinopathy cannot be supported.
	123.	The e-selectin C allele was more common in systemic lupus erythematosus than in controls. E-selectin may be a susceptibility gene to systemic lupus erythematosus in these populations.
	124.	E-selectin blood levels are no different in non-Hodgkin's lymphoma patients and controls
	125.	Tethering by E-selectin triggers b2-integrin-dependent adhesion and a b2-integrin-dependent outside-in signal resulting in tyrosine phosphorylation of a 110 kDa protein, in human PMN.
	126.	in end-stage renal disease, the Leu554Phe polymorphism of E-selectin gene is associated with the severity of carotid atherosclerosis
	127.	Homozygosity for the S128R E-selectin allele appears to increase the risk for recurrent venous thromboembolism several fold.
	128.	A significant increase in allele frequencies of 128R of E-selectin and the associated genotype SR was observed in celiac disease patients.
	129.	The interval was significantly longer in IgA nephropathy patients with a homoallele of C in C1402T, C1402/C1402, of the E-selectin gene, or a homoallele of C in C712T, C712/C712, of the L-selectin gene compared to others.
	130.	We were not able to demonstrate an association between the Hemicentin-1, hOgg1, and E-selectin SNPs and age-related macular degeneration development in the currently available cases and controls.
	131.	HOSCN induces E-selectin, ICAM-1, and VCAM-1 expression in HUVEC; HOSCN up-regulation of these adhesion molecules is transcriptionally mediated through a mechanism dependent upon activation of NFKB and constitutively suppressed by PI3K-Akt pathway.
	132.	the risk of acquiring coronary artery disease in patients with type 2 diabetes mellitus increases significantly in the presence of the 128R mutant allele of the E-selectin gene
	133.	Coexpression of E-selectin with ICAM-1 and CCL17 on blood vessels in noninflamed skin provides the basis for a model of cutaneous immunosurveillance system active in the absence of pathologic inflammation.
	134.	E-selectin has a role in tumor cell adhesion but its expression is inhibited by lovastatin and all-trans retinoic acid
	135.	In myeloperoxidase-ANCA-positive microscopic polyangiitis, higher sICAM-1 and sELAM-1 levels during active phase and their slower decline during treatment period could be prognostic risk factor for chronic renal failure.
	136.	results showed that sP-selectin and sE-selectin levels were higher in patients with lung cancer compared to normal donors; increased levels of sP-selectin and sE-selectin were associated with squamous lung cancer at late stages but not adenocarcinoma
	137.	interacts with Helicobacter pylori isolates from patients with chronic gastritis, duodenal ulcer and gastric cancer
	138.	relation between glycemic control, hyperinsulinism and plasma concentration in patints with glucose intolerance or NIDDM
	139.	E-selectin and vWF were not correlated with percent body fat, but were negatively correlated with M (r= -0.65 and -0.46, both P<0.001) and positively correlated with CRP (r=0.46, and 0.33, both P<0.05).
	140.	Genomic rearrangement on SELE in arteriosclerosis was studied.
	141.	HOXA9 participates in the transcriptional activation of SELE in endothelial cells.
	142.	High serum soluble E-selectin levels are associated with postoperative haematogenic recurrence in esophageal squamous cell carcinoma
	143.	the preferential expression of selectin E on the endothelium of femoral and iliac arteries in thromboangiitis obliterans
	144.	Clustered monocyte cell adhesion correlated with endothelial cells coexpressing intercellular adhesion molecule-1 (ICAM-1) and E-selectin as result of a flow-induced, selective upregulation of E-selectin expression in a subset of ICAM-1-expressing cells.
	145.	Blood levels do not differ in normal and coronary artery disease patients.
	146.	expression of HCELL confers robust and predominant tumor cell binding to E- and L-selectin
	147.	The mutant 128R allele of the E-selectin gene is associated with angiographic severe coronary artery disease (CAD) in Saudi Arabs. This association is lost after adjustment for traditional CAD risk factors.
	148.	Our results show that E-selectin gene polymorphisms represent an increased risk for ischemic CVD in the Japanese population without diabetes mellitus and hypercholesterolemia.
	149.	Increased plasma levels of E-selectin is associated with advanced stage of breast cancer
	150.	higher levels of E-selectin and ICAM-1 were consistently associated with increased diabetes risk in a multiethnic cohort of U.S. postmenopausal women, implicating an etiological role of endothelial dysfunction in the pathogenesis of type 2 diabetes.
	151.	activation of expression by HIV-1 tat protein via NF-kappa B-dependent mechanism

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[Top][Help]HIV-1 protein interactions

Protein		Interaction
1. Tat		HIV-1 Tat upregulates E-selectin (ELAM-1) in endothelial cells via an NF-kappa B-dependent mechanism		PubMed

Go to the HIV-1, Human Protein Interaction Database

[Top][Help]Interactions

Description ..........
Product	Interactant	Other Gene	Complex	Source	Pubs
The TAF12/ATF7 complex interacts with the E-selectin promoter.
NC_000001.8				BIND	PubMed

NP_000441.1	Alpha actinin 2	ACTN2		HPRD	PubMed

NP_000441.1	NP_000601.2	CD44		HPRD	PubMed

NP_000441.1	Filamin A	FLNA		HPRD	PubMed

NP_000441.1	Golgi apparatus protein 1	GLG1		HPRD	PubMed

NP_000441.1	Phospholipase C, gamma 1	PLCG1		HPRD	PubMed

NP_000441.1	FAK	PTK2		HPRD	PubMed

NP_000441.1	SHP2	PTPN11		HPRD	PubMed

NP_000441.1	Paxillin	PXN		HPRD	PubMed

NP_000441.1	Selectin L	SELL		HPRD	PubMed

NP_000441.1	Q14242	SELPLG		HPRD	PubMed

NP_000441.1	Complement component 1 inhibitor	SERPING1		HPRD	PubMed

NP_000441.1	Vinculin	VCL		HPRD	PubMed
Reconstituted Complex
BioGRID:112301	BioGRID:108996	GLG1		BioGRID	PubMed
Affinity Capture-Western
BioGRID:112301	BioGRID:111351	PLCG1		BioGRID	PubMed
Affinity Capture-Western
BioGRID:112301	BioGRID:111719	PTK2		BioGRID	PubMed
Affinity Capture-Western
BioGRID:112301	BioGRID:111745	PTPN11		BioGRID	PubMed
Affinity Capture-Western
BioGRID:112301	BioGRID:111787	PXN		BioGRID	PubMed
Affinity Capture-Luminescence
BioGRID:112301	BioGRID:112302	SELL		BioGRID	PubMed
Affinity Capture-Western
BioGRID:112301	BioGRID:107171	SERPING1		BioGRID	PubMed
Affinity Capture-Western
BioGRID:112301	BioGRID:112949	TLN1		BioGRID	PubMed

[Top][Help]General gene information

Markers

RH17688(e-PCR): Links: UniSTS:29198

D1S3668(e-PCR): Links: UniSTS:473924

D1S332(e-PCR): Links: UniSTS:148053

D1S3363(e-PCR): Links: UniSTS:41618

GDB:592877(e-PCR): Links: UniSTS:157929

PMC97258P1(e-PCR): Links: UniSTS:273644

Phenotypes

Atherosclerosis, susceptibility to: MIM: 131210
Blood pressure regulation QTL: MIM: 145500
IgA nephropathy, susceptiblity to: MIM: 161950

Genotypes

See SELE SNP Genotype Report

See SELE SNP Geneview Report

Homology

Homologs of the SELE gene The SELE gene is conserved in chimpanzee, dog, mouse, rat, and chicken.

Map Viewer (Mouse, Rat)

Pathways

KEGG pathway: Cell adhesion molecules (CAMs): 04514

Gene Ontology Provided by GOA

Function	Evidence
oligosaccharide binding	IDA	PubMed
phospholipase binding	IDA	PubMed
protein binding	IEA
sialic acid binding	IDA	PubMed
sugar binding	IEA
transmembrane receptor activity	IMP	PubMed

Process	Evidence
actin filament-based process	IDA	PubMed
activation of phospholipase C activity	IMP	PubMed
calcium-mediated signaling	TAS	PubMed
cell adhesion	IEA
heterophilic cell adhesion	IMP	PubMed
leukocyte migration during inflammatory response	TAS	PubMed
leukocyte tethering or rolling	IMP	PubMed
positive regulation of receptor internalization	IDA	PubMed
regulation of inflammatory response	TAS	PubMed
response to interleukin-1	IDA	PubMed
response to lipopolysaccharide	TAS	PubMed
response to tumor necrosis factor	TAS	PubMed

Component	Evidence
caveola	IDA	PubMed
coated pit	IDA	PubMed
cortical cytoskeleton	IDA	PubMed
extracellular space	IDA	PubMed
integral to membrane	IEA
perinuclear region of cytoplasm	IDA	PubMed
plasma membrane	TAS	PubMed

[Top][Help]General protein information

Preferred Names: selectin E

Names: selectin E; endothelial adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2

[Top][Help]NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

Genomic

NG_012124.1 RefSeqGene

Range

5000..16439

Download

GenBank FASTA Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000450.2 → NP_000441.2 selectin E precursor

Source sequence(s)

BC142711,DB209354

Consensus CDS

CCDS1283.1

UniProtKB/TrEMBL

A2RRD6

UniProtKB/Swiss-Prot

P16581

Conserved Domains (3) summary

cd00033
Location:367 – 426
Blast Score: 137

CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues...

cd03592
Location:22 – 140
Blast Score: 410

CLECT_selectins_like; CLECT_selectins_like: C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels). CTLD refers to a domain homologous to the carbohydrate-recognition...

cl09941
Location:145 – 174
Blast Score: 90

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...

RefSeqs of Annotated Genomes: Build 37.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Genome Reference Consortium Human Build 37 (GRCh37), Primary_Assembly

Genomic

NC_000001.10

Range

169691780..169703219, complement

Download

GenBank FASTA Sequence Viewer (Graphics)
NT_004487.19

Range

21180422..21191861, complement

Download

GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (Celera)

Genomic

AC_000044.1

Range

142801586..142813011, complement

Download

GenBank FASTA Sequence Viewer (Graphics)
NW_926128.1

Range

8056345..8067770, complement

Download

GenBank FASTA Sequence Viewer (Graphics)

Alternate assembly (HuRef)

Genomic

AC_000133.1

Range

140914126..140925551

Download

GenBank FASTA Sequence Viewer (Graphics)
NW_001838533.2

Range

36179699..36191124

Download

GenBank FASTA Sequence Viewer (Graphics)

[Top][Help]Related Sequences

Nucleotide		Protein
genomic	AF540378.1	AAN01237.1
genomic	AL021940.1	CAA17434.1
		CAI19357.1
		CAI19358.1
		CAI19359.1
		CAI19360.1
genomic	AL021940.1	CAA17434.1
		CAI19357.1
		CAI19358.1
		CAI19359.1
		CAI19360.1
genomic	CH471067.1	EAW90860.1
genomic	M61892.1	AAA52375.1
genomic	M61893.1	AAA52375.1
mRNA	AK314214.1	BAG36888.1
mRNA	AY367062.1	AAQ67702.1
mRNA	BC131551.1	AAI31552.1
mRNA	BC142677.1	AAI42678.1
mRNA	BC142711.1	AAI42712.1
mRNA	DB209354.1	None
mRNA	M24736.1	AAA52376.1
mRNA	M30640.1	AAA52377.1