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    SMOC2 SPARC related modular calcium binding 2 [ Bos taurus (cattle) ]

    Gene ID: 615490, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SMOC2provided by VGNC
    Official Full Name
    SPARC related modular calcium binding 2provided by VGNC
    Primary source
    VGNC:VGNC:35027
    See related
    BGD:BT28630; Ensembl:ENSBTAG00000013176
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 9
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (102645195..102803021)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101907159 Neighboring gene dishevelled binding antagonist of beta catenin 2 Neighboring gene uncharacterized LOC107132803 Neighboring gene uncharacterized LOC101907681 Neighboring gene uncharacterized LOC132346153

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC148871

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SPARC-related modular calcium-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098134.1 → NP_001091603.1  SPARC-related modular calcium-binding protein 2 precursor

      See identical proteins and their annotated locations for NP_001091603.1

      Status: PROVISIONAL

      Source sequence(s)
      BC140672
      UniProtKB/TrEMBL
      A5D7T2, F1N126
      Related
      ENSBTAP00000090571.1, ENSBTAT00000103526.1
      Conserved Domains (6) summary
      smart00280
      Location:39 → 84
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:215 → 281
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00086
      Location:90 → 153
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam13499
      Location:351 → 409
      EF-hand_7; EF-hand domain pair
      pfam16597
      Location:154 → 212
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
      cl08302
      Location:351 → 409
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      102645195..102803021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024996839.2 → XP_024852607.1  SPARC-related modular calcium-binding protein 2 isoform X2

      UniProtKB/TrEMBL
      F1N126
      Related
      ENSBTAP00000056754.2, ENSBTAT00000074522.2
      Conserved Domains (6) summary
      smart00280
      Location:39 → 84
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:226 → 292
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00086
      Location:90 → 153
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam16597
      Location:154 → 223
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
      cd00252
      Location:358 → 389
      EFh_SPARC_EC; EF-hand motif [structural motif]
      cl25349
      Location:315 → 427
      EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins

    2. XM_024996838.2 → XP_024852606.1  SPARC-related modular calcium-binding protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A3Q1MID9
      Related
      ENSBTAP00000101057.1, ENSBTAT00000103685.1
      Conserved Domains (6) summary
      smart00280
      Location:39 → 84
      KAZAL; Kazal type serine protease inhibitors
      cd00191
      Location:215 → 281
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam00086
      Location:90 → 153
      Thyroglobulin_1; Thyroglobulin type-1 repeat
      pfam16597
      Location:154 → 212
      Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain
      cd00252
      Location:347 → 378
      EFh_SPARC_EC; EF-hand motif [structural motif]
      cl25349
      Location:304 → 416
      EFh_SPARC_EC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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