xpnpep3 X-prolyl aminopeptidase 3, mitochondrial [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: xpnpep3provided by ZNC
Official Full Name: X-prolyl aminopeptidase 3, mitochondrialprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2076
See related: Ensembl:ENSDARG00000007916 AllianceGenome:ZFIN:ZDB-GENE-040426-2076
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:76905
Summary: Predicted to enable aminopeptidase activity. Acts upstream of or within gastrulation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (25059502..25087008, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (24928954..24956454, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: xaa-Pro aminopeptidase 3; probable Xaa-Pro aminopeptidase 3

NP_996962.1

EC 3.4.11.9

XP_005171644.1

EC 3.4.11.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207079.1 → NP_996962.1 xaa-Pro aminopeptidase 3

See identical proteins and their annotated locations for NP_996962.1

Status: PROVISIONAL

Source sequence(s)

BC066473

UniProtKB/TrEMBL

Q6NYT0

Related

ENSDARP00000050244.5, ENSDART00000050245.6

Conserved Domains (3) summary

PRK10879
Location:71 → 508

PRK10879; proline aminopeptidase P II; Provisional

smart01011
Location:71 → 209

AMP_N; Aminopeptidase P, N-terminal domain

cd01087
Location:252 → 492

Prolidase; Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

25059502..25087008 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171587.4 → XP_005171644.1 probable Xaa-Pro aminopeptidase 3 isoform X1

UniProtKB/TrEMBL

A0A8M2BJE5

Conserved Domains (2) summary

smart01011
Location:71 → 209

AMP_N; Aminopeptidase P, N-terminal domain

cl00279
Location:252 → 349

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...