scgn secretagogin, EF-hand calcium binding protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scgnprovided by ZNC
Official Full Name: secretagogin, EF-hand calcium binding proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-82
See related: Ensembl:ENSDARG00000058732 AllianceGenome:ZFIN:ZDB-GENE-041010-82
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:100843
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within brain development. Predicted to be located in cytoplasm. Predicted to be active in several cellular components, including cytosol; dendrite; and terminal bouton. Orthologous to human SCGN (secretagogin, EF-hand calcium binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (6356460..6377702, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (6415782..6436990, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

X-ray structure of Danio rerio secretagogin: A hexa-EF-hand calcium sensor
Title: X-ray structure of Danio rerio secretagogin: A hexa-EF-hand calcium sensor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of presynaptic cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: secretagogin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005776.1 → NP_001005776.1 secretagogin

See identical proteins and their annotated locations for NP_001005776.1

Status: PROVISIONAL

Source sequence(s)

BC083168

UniProtKB/Swiss-Prot

Q5XJX1

Related

ENSDARP00000076090.3, ENSDART00000081649.4

Conserved Domains (3) summary

cd00051
Location:105 → 175

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam13499
Location:107 → 174

EF-hand_7; EF-hand domain pair

cl08302
Location:13 → 83

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007127.7 Reference GRCz11 Primary Assembly

Range

6356460..6377702 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021466744.1 → XP_021322419.1 secretagogin isoform X1

UniProtKB/TrEMBL

A0A8M9PD78

Conserved Domains (2) summary

cd15902
Location:13 → 41

EFh_HEF; EF-hand motif [structural motif]

cl23634
Location:13 → 172

EFh_HEF; EF-hand, calcium binding motif, found in the hexa-EF hand proteins family