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    aga aspartylglucosaminidase [ Danio rerio (zebrafish) ]

    Gene ID: 566517, updated on 27-Mar-2024

    Summary

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    Official Symbol
    agaprovided by ZNC
    Official Full Name
    aspartylglucosaminidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2311
    See related
    Ensembl:ENSDARG00000004889 AllianceGenome:ZFIN:ZDB-GENE-040426-2311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:77327
    Summary
    Predicted to enable N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Predicted to be involved in protein deglycosylation. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in aspartylglucosaminuria and lysosomal storage disease. Orthologous to human AGA (aspartylglucosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (36428432..36437249, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (36088127..36096935, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 4 Neighboring gene ankyrin repeat and SOCS box containing 5a Neighboring gene nei-like DNA glycosylase 3 Neighboring gene si:dkey-237h12.3 Neighboring gene tryptophan 2,3-dioxygenase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Singh SK, et al. Fish Shellfish Immunol, 2014 Sep. PMID 25014315
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC77327

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
    NP_001103751.1
    XP_021336717.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110281.1 → NP_001103751.1  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase precursor

      See identical proteins and their annotated locations for NP_001103751.1

      Status: PROVISIONAL

      Source sequence(s)
      BC154306
      UniProtKB/TrEMBL
      A0A8M1NEL9, A8KC00
      Related
      ENSDARP00000015588.6, ENSDART00000016728.9
      Conserved Domains (1) summary
      cd04513
      Location:21 → 323
      Glycosylasparaginase; Glycosylasparaginase and similar proteins

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      36428432..36437249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481042.1 → XP_021336717.1  N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform X1

      UniProtKB/TrEMBL
      A0A8M9PZ91
      Conserved Domains (1) summary
      cd04513
      Location:2 → 201
      Glycosylasparaginase; Glycosylasparaginase and similar proteins

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394921.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      204941..214062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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