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    med13b mediator complex subunit 13b [ Danio rerio (zebrafish) ]

    Gene ID: 564707, updated on 27-Mar-2024

    Summary

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    Official Symbol
    med13bprovided by ZNC
    Official Full Name
    mediator complex subunit 13bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-3529
    See related
    Ensembl:ENSDARG00000003910 AllianceGenome:ZFIN:ZDB-GENE-030131-3529
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    med13; fc43h07; fc43h08; wu:fb66c06; wu:fc43h07; wu:fc43h08; zgc:153454
    Summary
    Predicted to enable transcription coregulator activity. Acts upstream of or within neural crest cell migration. Predicted to be located in nucleus. Predicted to be part of mediator complex. Is expressed in blastomere; nervous system; pectoral fin; and pectoral fin bud. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human MED13 (mediator complex subunit 13). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (20060643..20125164, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (20124911..20189432, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene zgc:112083 Neighboring gene activator of transcription and developmental regulator AUTS2 b Neighboring gene exocyst complex component 3-like 2b Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14Ab

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Impaired development of neural-crest cell-derived organs and intellectual disability caused by MED13L haploinsufficiency. Utami KH, et al. Hum Mutat, 2014 Nov. PMID 25137640
    2. auts2 Features and Expression Are Highly Conserved during Evolution Despite Different Evolutionary Fates Following Whole Genome Duplication. Merdrignac C, et al. Cells, 2022 Aug 30. PMID 36078102, Free PMC Article
    3. Transcriptional Complexity and Distinct Expression Patterns of auts2 Paralogs in Danio rerio. Kondrychyn I, et al. G3 (Bethesda), 2017 Aug 7. PMID 28626003, Free PMC Article
    4. MicroRNA profile of immune response in gills of zebrafish (Danio rerio) upon Staphylococcus aureus infection. Zhang QL, et al. Fish Shellfish Immunol, 2019 Apr. PMID 30677514
    5. Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. Zheng D, et al. BMC Genomics, 2010 Oct 11. PMID 20937081, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0593

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 13-like
    Names
    mediator complex subunit 13
    thyroid hormone receptor-associated protein complex 240 kDa component-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083838.1 → NP_001077307.1  mediator of RNA polymerase II transcription subunit 13-like

      See identical proteins and their annotated locations for NP_001077307.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129032
      UniProtKB/Swiss-Prot
      A2VCZ5
      Related
      ENSDARP00000126727.1, ENSDART00000152355.2
      Conserved Domains (2) summary
      pfam06333
      Location:1584 → 2089
      Med13_C; Mediator complex subunit 13 C-terminal
      pfam11597
      Location:14 → 383
      Med13_N; Mediator complex subunit 13 N-terminal

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      20060643..20125164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VCZ5.1 GenPept UniProtKB/Swiss-Prot:A2VCZ5

    Gene LinkOut

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