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    Gbp3 guanylate binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 55932, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Gbp3provided by MGI
    Official Full Name
    guanylate binding protein 3provided by MGI
    Primary source
    MGI:MGI:1926263
    See related
    Ensembl:ENSMUSG00000028268 AllianceGenome:MGI:1926263
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gbp4; GBP-3; GBP-4
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Acts upstream of or within adhesion of symbiont to host; cellular response to interferon-beta; and defense response to other organism. Located in cytoplasmic vesicle; cytosol; and symbiont-containing vacuole membrane. Orthologous to human GBP4 (guanylate binding protein 4) and GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 10.8), subcutaneous fat pad adult (RPKM 6.0) and 21 other tissues See more
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    Genomic context

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    Location:
    3 H1; 3 66.69 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142265781..142278974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142560016..142573213)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene guanylate binding protein 5 Neighboring gene guanylate binding protein 7 Neighboring gene STARR-positive B cell enhancer ABC_E3478 Neighboring gene predicted gene, 40158 Neighboring gene STARR-positive B cell enhancer ABC_E10218 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142263123-142263423 Neighboring gene guanylate binding protein 2b Neighboring gene STARR-positive B cell enhancer mm9_chr3:142282846-142283147 Neighboring gene predicted gene, 54185 Neighboring gene microRNA 6381 Neighboring gene guanylate binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase. Vestal DJ, et al. J Interferon Cytokine Res, 2011 Jan. PMID 21142871, Free PMC Article
    2. GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair. Xu H, et al. Oncogene, 2022 Jul. PMID 35780181
    3. GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis. Xu H, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29128363
    4. Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells. Han BH, et al. Biochim Biophys Acta, 1998 May 19. PMID 9659399
    5. Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Meunier E, et al. Nature, 2014 May 15. PMID 24739961

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.
      Title: Gbp3 is associated with the progression of lupus nephritis by regulating cell proliferation, inflammation and pyroptosis.
    2. GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
      Title: GBP3 promotes glioblastoma resistance to temozolomide by enhancing DNA damage repair.
    3. GBP3 over-expression promotes glioma growth in mice and is inversely correlated with patients survival rate.
      Title: GBP3 promotes glioma cell proliferation via SQSTM1/p62-ERK1/2 axis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within adhesion of symbiont to host IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to interferon-beta IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytolysis in another organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within defense response to protozoan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of pyroptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in symbiont-containing vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylate-binding protein 3
    Names
    GTP-binding protein 3
    GTP-binding protein 4
    guanine nucleotide-binding protein 3
    guanine nucleotide-binding protein 4
    guanylate nucleotide binding protein 3
    guanylate nucleotide binding protein 4
    guanylate-binding protein 4
    putative purine nucleotide binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289492.3 → NP_001276421.1  guanylate-binding protein 3

      See identical proteins and their annotated locations for NP_001276421.1

      Status: VALIDATED

      Source sequence(s)
      AC102108, AK132266, CK389037
      Consensus CDS
      CCDS17879.1
      UniProtKB/Swiss-Prot
      Q61107, Q8VEC5
      Related
      ENSMUSP00000029935.8, ENSMUST00000029935.14
      Conserved Domains (2) summary
      pfam02263
      Location:12 → 275
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:277 → 573
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001289493.2 → NP_001276422.1  guanylate-binding protein 3

      See identical proteins and their annotated locations for NP_001276422.1

      Status: VALIDATED

      Source sequence(s)
      AC102108, AK132266, CK389037
      Consensus CDS
      CCDS17879.1
      UniProtKB/Swiss-Prot
      Q61107, Q8VEC5
      Related
      ENSMUSP00000101828.2, ENSMUST00000106221.8
      Conserved Domains (2) summary
      pfam02263
      Location:12 → 275
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:277 → 573
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001355403.2 → NP_001342332.1  guanylate-binding protein 3

      Status: VALIDATED

      Source sequence(s)
      AC102108
      Consensus CDS
      CCDS17879.1
      UniProtKB/Swiss-Prot
      Q61107, Q8VEC5
      Conserved Domains (2) summary
      pfam02263
      Location:12 → 275
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:277 → 573
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. NM_018734.4 → NP_061204.3  guanylate-binding protein 3

      See identical proteins and their annotated locations for NP_061204.3

      Status: VALIDATED

      Source sequence(s)
      AA162247, AC102108, AK132266
      Consensus CDS
      CCDS17879.1
      UniProtKB/Swiss-Prot
      Q61107, Q8VEC5
      Related
      ENSMUSP00000101829.3, ENSMUST00000106222.9
      Conserved Domains (2) summary
      pfam02263
      Location:12 → 275
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:277 → 573
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      142265781..142278974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501719.3 → XP_006501782.1  guanylate-binding protein 3 isoform X1

      Conserved Domains (2) summary
      pfam02263
      Location:72 → 335
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:337 → 633
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_006501724.3 → XP_006501787.1  guanylate-binding protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006501787.1

      UniProtKB/Swiss-Prot
      Q61107, Q8VEC5
      Conserved Domains (2) summary
      pfam02263
      Location:12 → 275
      GBP; Guanylate-binding protein, N-terminal domain
      pfam02841
      Location:277 → 573
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61107.1 GenPept UniProtKB/Swiss-Prot:Q61107

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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