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    STAP2 signal transducing adaptor family member 2 [ Homo sapiens (human) ]

    Gene ID: 55620, updated on 31-Mar-2024

    Summary

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    Official Symbol
    STAP2provided by HGNC
    Official Full Name
    signal transducing adaptor family member 2provided by HGNC
    Primary source
    HGNC:HGNC:30430
    See related
    Ensembl:ENSG00000178078 MIM:607881; AllianceGenome:HGNC:30430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BKS
    Summary
    This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in colon (RPKM 37.7), small intestine (RPKM 30.7) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STAP2 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (4324043..4338827, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (4307445..4326896, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4324040..4338824, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4301847-4302392 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9884 Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4326526-4327507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13767 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4342611-4343342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4350305-4350806 Neighboring gene MPN domain containing Neighboring gene eukaryotic translation initiation factor 1 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4365919-4366840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4368989-4369938 Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4369939-4370886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4372431-4373164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4373165-4373898 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr19:4374633-4375365 and GRCh37_chr19:4375366-4376099 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4377567-4378299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13773 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:4386482-4386982 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4389401-4390008 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4390009-4390615 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4390616-4391224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:4394991-4395501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:4399905-4400734

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells. Yamamoto T, et al. Biochem Biophys Res Commun, 2003 Jul 4. PMID 12810085
    2. Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases. Ichii M, et al. Exp Hematol, 2022 Jan. PMID 34780812
    3. STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells. Saitoh K, et al. Biochem Biophys Res Commun, 2017 Jun 17. PMID 28478037
    4. Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation. Muraoka D, et al. Oncotarget, 2017 May 9. PMID 28430604, Free PMC Article
    5. Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8. Sekine Y, et al. J Immunol, 2012 Jun 15. PMID 22611243

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
      Title: STAP-2 facilitates insulin signaling through binding to CAP/c-Cbl and regulates adipocyte differentiation.
    2. Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases.
      Title: Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases.
    3. These findings indicate an essential role for STAP2 in the generation of a high-quality memory CD8+ CTLs periphery, and suggest the therapeutic potential of STAP2 in cancer patients.
      Title: Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.
    4. High STAP2 expression is associated with prostate cancer.
      Title: STAP-2 protein promotes prostate cancer growth by enhancing epidermal growth factor receptor stabilization.
    5. The Pyk2/STAP-2 interaction is a novel mechanism to regulate SDF-1alpha-dependent T-cell chemotaxis.
      Title: STAP-2 interacts with Pyk2 and enhances Pyk2 activity in T-cells.
    6. STAP2 is upregulated in uterosacral ligaments in pelvic organ prolapse
      Title: Estrogen-related genome-based expression profiling study of uterosacral ligaments in women with pelvic organ prolapse.
    7. Our results demonstrate a critical contribution of STAP-2 in BCR-ABL activity.
      Title: STAP-2 interacts with and modulates BCR-ABL-mediated tumorigenesis.
    8. STAP-2 is a novel participant in the regulation of T cell apoptosis after stimulation
      Title: Signal-transducing adaptor protein-2 modulates Fas-mediated T cell apoptosis by interacting with caspase-8.
    9. Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
      Title: Interactions of STAP-2 with Brk and STAT3 participate in cell growth of human breast cancer cells.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20234

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    signal-transducing adaptor protein 2
    Names
    BRK substrate
    breast tumor kinase substrate
    brk kinase substrate

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013841.2 → NP_001013863.1  signal-transducing adaptor protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001013863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
      Source sequence(s)
      AC104521, BC000795, BF677969
      Consensus CDS
      CCDS45926.1
      UniProtKB/Swiss-Prot
      A6NKK3, Q9NXI2, Q9UGK3
      Related
      ENSP00000471052.1, ENST00000594605.6
      Conserved Domains (2) summary
      cd10404
      Location:151 → 247
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cd13268
      Location:9 → 136
      PH_Brdg1; BCR downstream signaling 1 Pleckstrin homology (PH) domain

    2. NM_017720.3 → NP_060190.2  signal-transducing adaptor protein 2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC008616, AC104521, AK000241, BF677969
      Consensus CDS
      CCDS12128.1
      UniProtKB/Swiss-Prot
      Q9UGK3
      Related
      ENSP00000468927.1, ENST00000600324.5
      Conserved Domains (2) summary
      cd10404
      Location:151 → 247
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cd13268
      Location:9 → 136
      PH_Brdg1; BCR downstream signaling 1 Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      4324043..4338827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528123.2 → XP_011526425.1  signal-transducing adaptor protein 2 isoform X1

      Conserved Domains (2) summary
      cd10404
      Location:151 → 247
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cd13268
      Location:9 → 136
      PH_Brdg1; BCR downstream signaling 1 Pleckstrin homology (PH) domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      4307445..4326896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321404.1 → XP_054177379.1  signal-transducing adaptor protein 2 isoform X2

    2. XM_054321403.1 → XP_054177378.1  signal-transducing adaptor protein 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UGK3.2 GenPept UniProtKB/Swiss-Prot:Q9UGK3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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