slc30a10 solute carrier family 30 member 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: slc30a10provided by ZNC
Official Full Name: solute carrier family 30 member 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-060608-2
See related: Ensembl:ENSDARG00000103983 AllianceGenome:ZFIN:ZDB-GENE-060608-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ZnT10
Summary: Predicted to enable zinc ion transmembrane transporter activity. Acts upstream of or within manganese ion homeostasis and manganese ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in brain; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to human SLC30A10 (solute carrier family 30 member 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (51966572..51973733, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (51757040..51764478, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

xpressing either wild-type or mutant forms of SLC30A10 was sufficient to inhibit the effect of ATP2C1 in response to Mn challenge in both zebrafish embryos and HeLa cells. These findings suggest that either activating ATP2C1 or restoring the Mn-induced trafficking of ATP2C1 can reduce Mn accumulation, providing a possible target for treating HMDPC.
Title: Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis.

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General gene information

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Markers

Z8617 (e-PCR)
- UniSTS:44457

fk56e12.x1 (e-PCR)
- UniSTS:201209

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in detoxification of zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within manganese ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within manganese ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc transporter 10

Names: solute carrier family 30 (zinc transporter), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128234.2 → NP_001121706.2 zinc transporter 10

Status: VALIDATED

Source sequence(s)

FO203516

UniProtKB/TrEMBL

A0A0R4IEQ2, A0A8M3AZG9, A8WFU0

Related

ENSDARP00000132768.1, ENSDART00000166701.2

Conserved Domains (1) summary

COG1230
Location:10 → 330

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

51966572..51973733 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009307624.3 → XP_009305899.1 zinc transporter 10 isoform X1

UniProtKB/TrEMBL

A0A0R4IEQ2

Conserved Domains (1) summary

COG1230
Location:10 → 330

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]