PKLR pyruvate kinase L/R [Bos taurus (cattle)] - Gene

Summary

Official Symbol: PKLRprovided by VGNC
Official Full Name: pyruvate kinase L/Rprovided by VGNC
Primary source: VGNC:VGNC:32943
See related: BGD:BT12238; Ensembl:ENSBTAG00000017056
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (15344803..15354042)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables potassium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables pyruvate kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: pyruvate kinase PKLR

Names: pyruvate kinase isozymes R/L; pyruvate kinase, liver and RBC

NP_001069644.1

EC 2.7.1.40

XP_059740779.1

EC 2.7.1.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001076176.1 → NP_001069644.1 pyruvate kinase PKLR

See identical proteins and their annotated locations for NP_001069644.1

Status: PROVISIONAL

Source sequence(s)

BT025386

UniProtKB/TrEMBL

Q1JPG7

Related

ENSBTAP00000044193.2, ENSBTAT00000046947.3

Conserved Domains (1) summary

cd00288
Location:37 → 525

Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...