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    ABCC8 ATP binding cassette subfamily C member 8 [ Bos taurus (cattle) ]

    Gene ID: 538996, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ABCC8provided by VGNC
    Official Full Name
    ATP binding cassette subfamily C member 8provided by VGNC
    Primary source
    VGNC:VGNC:25475
    See related
    BGD:BT12995; Ensembl:ENSBTAG00000000983
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 15
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (35030382..35109471)

    Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene otogelin Neighboring gene USH1 protein network component harmonin Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene natural killer cell cytotoxicity receptor 3 ligand 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables sulfonylurea receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family C member 8
    Names
    ATP-binding cassette, sub-family C (CFTR/MRP), member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205610.3 → NP_001192539.1  ATP-binding cassette sub-family C member 8

      See identical proteins and their annotated locations for NP_001192539.1

      Status: PROVISIONAL

      Source sequence(s)
      NKLS02000015
      Related
      ENSBTAP00000080005.1, ENSBTAT00000104745.1
      Conserved Domains (4) summary
      TIGR01271
      Location:223 → 1581
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      pfam00664
      Location:1016 → 1294
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:375 → 590
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1342 → 1581
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      35030382..35109471
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005216038.5 → XP_005216095.1  ATP-binding cassette sub-family C member 8 isoform X1

      UniProtKB/TrEMBL
      E1BKR6
      Related
      ENSBTAP00000043950.4, ENSBTAT00000046676.5
      Conserved Domains (4) summary
      TIGR01271
      Location:223 → 1584
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      pfam00664
      Location:1017 → 1297
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:375 → 590
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1345 → 1584
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_010812502.4 → XP_010810804.1  ATP-binding cassette sub-family C member 8 isoform X2

      Conserved Domains (4) summary
      TIGR01271
      Location:223 → 1583
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      pfam00664
      Location:1016 → 1296
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:375 → 590
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1344 → 1583
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_005216041.5 → XP_005216098.1  ATP-binding cassette sub-family C member 8 isoform X4

      Conserved Domains (4) summary
      COG1132
      Location:297 → 933
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
      pfam00664
      Location:1017 → 1254
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:375 → 590
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:679 → 907
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_005216040.5 → XP_005216097.1  ATP-binding cassette sub-family C member 8 isoform X3

      Conserved Domains (4) summary
      TIGR01271
      Location:87 → 1448
      CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
      pfam00664
      Location:881 → 1161
      ABC_membrane; ABC transporter transmembrane region
      cl00549
      Location:239 → 454
      ABC_membrane; ABC transporter transmembrane region
      cl21455
      Location:1209 → 1448
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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