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    ROBO1 roundabout guidance receptor 1 [ Bos taurus (cattle) ]

    Gene ID: 536815, updated on 3-Apr-2024

    Summary

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    Official Symbol
    ROBO1provided by VGNC
    Official Full Name
    roundabout guidance receptor 1provided by VGNC
    Primary source
    VGNC:VGNC:34078
    See related
    BGD:BT24767; Ensembl:ENSBTAG00000009851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See ROBO1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (26116519..27412512, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene uncharacterized LOC132345460 Neighboring gene uncharacterized LOC100848584 Neighboring gene apoptosis-resistant E3 ubiquitin protein ligase 1-like Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA cysteine (anticodon ACA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables axon guidance receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Roundabout signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in axon midline choice point recognition IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    roundabout homolog 1
    Names
    roundabout, axon guidance receptor, homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001192888.3 → NP_001179817.2  roundabout homolog 1 precursor

      See identical proteins and their annotated locations for NP_001179817.2

      Status: VALIDATED

      Source sequence(s)
      NKLS02000001
      UniProtKB/TrEMBL
      F1N739
      Related
      ENSBTAP00000088348.1, ENSBTAT00000101606.1
      Conserved Domains (8) summary
      cd05724
      Location:174 → 258
      Ig2_Robo; Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05725
      Location:279 → 347
      Ig3_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd05726
      Location:368 → 457
      Ig4_Robo; Third immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
      cd07693
      Location:67 → 166
      Ig1_Robo; First immunoglobulin (Ig)-like domain in Robo (roundabout) receptors and similar proteins
      cd00063
      Location:564 → 650
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:262 → 347
      I-set; Immunoglobulin I-set domain
      pfam00041
      Location:781 → 867
      fn3; Fibronectin type III domain
      cl11960
      Location:462 → 536
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26116519..27412512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885533.1 → XP_059741516.1  roundabout homolog 1 isoform X3

      Related
      ENSBTAP00000092386.1, ENSBTAT00000095029.1

    2. XM_059885537.1 → XP_059741520.1  roundabout homolog 1 isoform X5

    3. XM_059885531.1 → XP_059741514.1  roundabout homolog 1 isoform X2

    4. XM_059885536.1 → XP_059741519.1  roundabout homolog 1 isoform X4

    5. XM_059885529.1 → XP_059741512.1  roundabout homolog 1 isoform X1

    6. XM_059885552.1 → XP_059741535.1  roundabout homolog 1 isoform X9

    7. XM_059885547.1 → XP_059741530.1  roundabout homolog 1 isoform X8

    8. XM_059885545.1 → XP_059741528.1  roundabout homolog 1 isoform X7

    9. XM_059885541.1 → XP_059741524.1  roundabout homolog 1 isoform X6

      Related
      ENSBTAP00000053683.4, ENSBTAT00000061264.4
    Nucleotide Protein Strain
    Heading Accession and Version

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