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    PRKG2 protein kinase cGMP-dependent 2 [ Bos taurus (cattle) ]

    Gene ID: 533330, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PRKG2provided by VGNC
    Official Full Name
    protein kinase cGMP-dependent 2provided by VGNC
    Primary source
    VGNC:VGNC:33341
    See related
    BGD:BT19450; Ensembl:ENSBTAG00000002978
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 6
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (95867278..96003716, complement)

    Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 299 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene bone morphogenetic protein 3 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene uncharacterized LOC112447109 Neighboring gene RasGEF domain family member 1B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2. Koltes JE, et al. BMC Res Notes, 2015 Apr 30. PMID 25924610, Free PMC Article
    2. A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle. Koltes JE, et al. Proc Natl Acad Sci U S A, 2009 Nov 17. PMID 19887637, Free PMC Article
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study indicates that loss of PRKG2 function results in differential expression of P53 regulated genes as well as additional pathways consistent with increased proliferation and apoptosis in the growth plate due to achondroplastic dwarfism.
      Title: Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2.
    2. PRKG2 R678X as a causative mutation for dwarfism cattle was presented.
      Title: A nonsense mutation in cGMP-dependent type II protein kinase (PRKG2) causes dwarfism in American Angus cattle.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cGMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cGMP-dependent protein kinase 2
    Names
    cGMP-dependant type II protein kinase
    protein kinase, cGMP-dependent, type II
    NP_001137571.1
    XP_024849054.1
    XP_024849057.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144099.1 → NP_001137571.1  cGMP-dependent protein kinase 2

      See identical proteins and their annotated locations for NP_001137571.1

      Status: INFERRED

      Source sequence(s)
      AAFC03077638, AAFC03077640, AAFC03077642, AAFC03077643
      UniProtKB/TrEMBL
      D5HSX1, F1MDQ6
      Related
      ENSBTAP00000003877.5, ENSBTAT00000003877.5
      Conserved Domains (2) summary
      cd00038
      Location:286 → 401
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:459 → 718
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      95867278..96003716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024993286.2 → XP_024849054.1  cGMP-dependent protein kinase 2 isoform X1

      UniProtKB/TrEMBL
      D5HSX1, F1MDQ6
      Conserved Domains (2) summary
      cd00038
      Location:286 → 401
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd05572
      Location:459 → 718
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)

    2. XM_024993289.2 → XP_024849057.1  cGMP-dependent protein kinase 2 isoform X2

      Conserved Domains (1) summary
      cd05572
      Location:1 → 238
      STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
    Nucleotide Protein Strain
    Heading Accession and Version

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