GCLM glutamate-cysteine ligase modifier subunit [Bos taurus (cattle)] - Gene

Summary

Official Symbol: GCLMprovided by VGNC
Official Full Name: glutamate-cysteine ligase modifier subunitprovided by VGNC
Primary source: VGNC:VGNC:29290
See related: BGD:BT29483; Ensembl:ENSBTAG00000007842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (49581839..49599565)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

MARC_33856-33857:1053626521:1 (e-PCR)
- UniSTS:466802

MARC_33872-33873:1054212607:1 (e-PCR)
- UniSTS:466809

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables enzyme regulator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables glutamate-cysteine ligase catalytic subunit binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of glutamate-cysteine ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of glutamate-cysteine ligase complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glutamate--cysteine ligase regulatory subunit

Names: GCS light chain; gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit

NP_001033232.1

EC 6.3.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038143.1 → NP_001033232.1 glutamate--cysteine ligase regulatory subunit

See identical proteins and their annotated locations for NP_001033232.1

Status: PROVISIONAL

Source sequence(s)

BC111206

UniProtKB/Swiss-Prot

Q2T9Y6

Related

ENSBTAP00000026855.3, ENSBTAT00000026855.4

Conserved Domains (1) summary

cl00470
Location:117 → 256

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...