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    SMAD6 SMAD family member 6 [ Bos taurus (cattle) ]

    Gene ID: 511279, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SMAD6provided by VGNC
    Official Full Name
    SMAD family member 6provided by VGNC
    Primary source
    VGNC:VGNC:34979
    See related
    BGD:BT12049; Ensembl:ENSBTAG00000000625
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    Smad6-like
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 10
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (13544385..13622063)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD18 Neighboring gene zwilch kinetochore protein Neighboring gene uncharacterized LOC112441475 Neighboring gene ribosomal protein L4 Neighboring gene lactase like Neighboring gene transfer RNA serine (anticodon GGA) Neighboring gene uncharacterized LOC107132820 Neighboring gene uncharacterized LOC132346331 Neighboring gene SMAD family member 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transcription regulator inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206145.2 → NP_001193074.1  mothers against decapentaplegic homolog 6

      See identical proteins and their annotated locations for NP_001193074.1

      Status: VALIDATED

      Source sequence(s)
      NKLS02000010
      UniProtKB/TrEMBL
      A0A3Q1M0V0
      Related
      ENSBTAP00000058156.1, ENSBTAT00000081089.1
      Conserved Domains (2) summary
      cd10493
      Location:160 → 273
      MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
      cd10499
      Location:322 → 495
      MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      13544385..13622063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024997426.2 → XP_024853194.1  mothers against decapentaplegic homolog 6 isoform X2

      Related
      ENSBTAP00000000824.4, ENSBTAT00000000824.4
      Conserved Domains (2) summary
      cd10493
      Location:160 → 273
      MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
      cd10499
      Location:296 → 469
      MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6

    2. XM_024997425.2 → XP_024853193.1  mothers against decapentaplegic homolog 6 isoform X1

      UniProtKB/TrEMBL
      E1BH37
      Related
      ENSBTAP00000063293.2, ENSBTAT00000077858.2
      Conserved Domains (2) summary
      cd10493
      Location:160 → 273
      MH1_SMAD_6; N-terminal Mad Homology 1 (MH1) domain in SMAD6
      cd10499
      Location:354 → 527
      MH2_SMAD_6; C-terminal Mad Homology 2 (MH2) domain in SMAD6
    Nucleotide Protein Strain
    Heading Accession and Version

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