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    GOLGA7 golgin A7 [ Homo sapiens (human) ]

    Gene ID: 51125, updated on 5-Mar-2024

    Summary

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    Official Symbol
    GOLGA7provided by HGNC
    Official Full Name
    golgin A7provided by HGNC
    Primary source
    HGNC:HGNC:24876
    See related
    Ensembl:ENSG00000147533 MIM:609453; AllianceGenome:HGNC:24876
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCP16; GOLGA7A; HSPC041; GOLGA3AP1
    Summary
    Involved in Golgi to plasma membrane protein transport; peptidyl-L-cysteine S-palmitoylation; and protein stabilization. Acts upstream of or within Golgi to plasma membrane transport. Located in Golgi membrane and Golgi stack. Is intrinsic component of Golgi membrane. Part of palmitoyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 33.3), testis (RPKM 26.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    8p11.21
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (41490396..41510980)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (41764091..41784672)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (41347915..41368499)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9460 Neighboring gene small nucleolar RNA, C/D box 65B Neighboring gene uncharacterized LOC105379391 Neighboring gene uncharacterized LOC124901938 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19142 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27284 Neighboring gene keratin 18 pseudogene 37 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19143 Neighboring gene GPAT4 and GINS4 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27285 Neighboring gene GINS complex subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry. Zeng XT, et al. Virol J, 2021 Dec 27. PMID 34961524, Free PMC Article
    2. Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170. Ohta E, et al. J Biol Chem, 2003 Dec 19. PMID 14522980
    3. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. Swarthout JT, et al. J Biol Chem, 2005 Sep 2. PMID 16000296
    4. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang T, et al. Cell, 2017 Feb 23. PMID 28162770, Free PMC Article
    5. Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis. Jia L, et al. Genomics, 2002 Jan. PMID 11827452

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
      Title: The interactions of ZDHHC5/GOLGA7 with SARS-CoV-2 spike (S) protein and their effects on S protein's subcellular localization, palmitoylation and pseudovirus entry.
    2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    4. results indicate that GCP16 is the acylated membrane protein, associated with GCP170, and possibly involved in vesicular transport from the Golgi to the cell surface
      Title: Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.
    5. Data show that H- and N-Ras are palmitoylated by a human protein palmitoyltransferase encoded by the ZDHHC9 and GCP16 genes.
      Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4876, MGC21096

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within Golgi to plasma membrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    part_of palmitoyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of palmitoyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in tertiary granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 7
    Names
    Golgi complex-associated protein of 16kDa
    golgi autoantigen, golgin subfamily a, 7
    golgi complex-associated protein of 16 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002296.2 → NP_001002296.1  golgin subfamily A member 7 isoform a

      See identical proteins and their annotated locations for NP_001002296.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).
      Source sequence(s)
      AC009630, AF068291, AF125102, AV650886, BC001227, BC012032, BG939345
      Consensus CDS
      CCDS34887.1
      UniProtKB/Swiss-Prot
      D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
      UniProtKB/TrEMBL
      A0A8Q3WLM5
      Related
      ENSP00000350378.4, ENST00000357743.9
      Conserved Domains (1) summary
      pfam10256
      Location:12 → 124
      Erf4; Golgin subfamily A member 7/ERF4 family

    2. NM_001174124.2 → NP_001167595.1  golgin subfamily A member 7 isoform b

      See identical proteins and their annotated locations for NP_001167595.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 2. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC009630, AK026613, BC001227
      Consensus CDS
      CCDS55226.1
      UniProtKB/TrEMBL
      A0A8Q3WLM5
      Related
      ENSP00000386030.2, ENST00000405786.3
      Conserved Domains (1) summary
      pfam10256
      Location:12 → 123
      Erf4; Golgin subfamily A member 7/ERF4 family

    3. NM_001362979.1 → NP_001349908.1  golgin subfamily A member 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      AF068291, AF125102, AV650886, BC001227, BG939345, BI546026
      Consensus CDS
      CCDS34887.1
      UniProtKB/Swiss-Prot
      D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
      UniProtKB/TrEMBL
      A0A8Q3WLM5
      Related
      ENSP00000429329.1, ENST00000518270.6
      Conserved Domains (1) summary
      pfam10256
      Location:12 → 124
      Erf4; Golgin subfamily A member 7/ERF4 family

    4. NM_001362980.2 → NP_001349909.1  golgin subfamily A member 7 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC009630, AF068291, AF125102, AV650886, BC001227, BG939345, BP341683, HY131836
      Consensus CDS
      CCDS34887.1
      UniProtKB/Swiss-Prot
      D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
      UniProtKB/TrEMBL
      A0A8Q3WLM5
      Related
      ENSP00000511570.1, ENST00000694887.1
      Conserved Domains (1) summary
      pfam10256
      Location:12 → 124
      Erf4; Golgin subfamily A member 7/ERF4 family

    5. NM_016099.3 → NP_057183.2  golgin subfamily A member 7 isoform a

      See identical proteins and their annotated locations for NP_057183.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2, and encodes the longer isoform (a). Variants 1, 2, 4 and 5 encode the same isoform (a).
      Source sequence(s)
      AF068291, AF125102, AV650886, BC001227, BC012032, BG939345, BI553491
      Consensus CDS
      CCDS34887.1
      UniProtKB/Swiss-Prot
      D3DSX9, J3KQ24, Q7Z5G4, Q96EQ4, Q9P1S0, Q9Y5U7
      UniProtKB/TrEMBL
      A0A8Q3WLM5
      Related
      ENSP00000510742.1, ENST00000687203.1
      Conserved Domains (1) summary
      pfam10256
      Location:12 → 124
      Erf4; Golgin subfamily A member 7/ERF4 family

    RNA

    1. NR_156425.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009630, AF068291, AF125102, AV650886, BC001227, BG939345, BP341683
      Related
      ENST00000694913.1

    2. NR_156426.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF068291, AF125102, AV650886, BC001227, BG939345, HY136581
      Related
      ENST00000520817.6

    3. NR_156427.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF068291, AF125102, AV650886, BC001227, BG939345, HY099624, HY136581
      Related
      ENST00000694863.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      41490396..41510980
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      41764091..41784672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z5G4.2 GenPept UniProtKB/Swiss-Prot:Q7Z5G4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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